The American Journal of Digestive Diseases

, Volume 19, Issue 5, pp 439–448 | Cite as

Effects of capsaicin in combination with diets of varying protein content on the duodenal absorptive cells of the rat

  • Waykin Nopanitaya
Original Articles


The effects of capsaicin, a pungent principle of capsicum pepper, and its combination with various diets on the morphology of duodenal mucosa was studied on young rats grouped and maintained on six different diets for periods of 28 and 56 days: normal diet with and without capsaicin, high-protein diet with and without capsaicin, and low-protein diet with and without capsaicin. Goblet cells in the capsaicin-treated animals increased in number. Ultrastructural alterations occurred in absorptive cells of rats fed a low-protein diet and also in those fed diets supplemented with capsaicin for both 28 and 56 days. The most striking ultrastructural alterations developed in animals that received the low-protein diet supplemented with capsaicin. This study shows that capsaicin intensifies the morphological alterations associated with a low-protein diet.


Public Health Protein Content Capsaicin Goblet Cell Normal Diet 
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Copyright information

© Digestive Disease Systems, Inc. 1974

Authors and Affiliations

  • Waykin Nopanitaya
    • 1
  1. 1.Department of Pathology, School of MedicineUniversity of North CarolinaChapel Hill

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