The American Journal of Digestive Diseases

, Volume 19, Issue 5, pp 411–416 | Cite as

Effect of administered human growth hormone on growth retardation in inflammatory bowel disease

  • Thomas D. McCafferyJr.
  • Khosrow Nasr
  • A. M. Lawrence
  • Joseph B. Kirsner
Original Articles

Abstract

In a previous study of 22 severely growth-retarded children with inflammatory bowel disease (IBD), endocrinologic evaluation revealed hypogonadism and low growth hormone (HGH) levels. This was attributed to a secondary hypopituitarism. In order to assess this hypothesis, two individuals from this group and another similar child who was not so severely growth-retarded as to be included in the initial study were given HGH replacement in an acute trial and for a 6-month interval. No significant height increment could be attributed to the HGH administration although a definite anabolic response was present in each patient during the acute trial. It appears that the youngsters with IBD may have a relative end-organ resistance to the metabolic and growth-promoting effects of HGH and that their growth problems are not related to hypopituitarism.

Keywords

Growth Hormone Inflammatory Bowel Disease Growth Retardation Hypogonadism Human Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Digestive Disease Systems, Inc. 1974

Authors and Affiliations

  • Thomas D. McCafferyJr.
    • 1
  • Khosrow Nasr
    • 1
  • A. M. Lawrence
    • 1
  • Joseph B. Kirsner
    • 1
  1. 1.Gastroenterology and Endocrinology Sections, Department of MedicineUniversity of ChicagoChicago

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