European Journal of Nuclear Medicine

, Volume 23, Issue 11, pp 1473–1477 | Cite as

Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women

  • Vincenzo Carnevale
  • Vincenzo Frusciante
  • Alfredo Scillitani
  • Sergio Modoni
  • Mauro Pileri
  • Iacopo Chiodini
  • Franca Dicembrino
  • Elisabetta Romagnoli
  • Salvatore Minisola
Original Article

Abstract

A short-term evaluation of global skeletal uptake (GSU) of technetium-99m methylene diphosphonate (MDP) was performed in 40 healthy female subjects with a wide age range in order to investigate the clinical performance of the technique and to detect the age-related changes in bone turnover. The results obtained were compared with measurements of the main biochemical markers of skeletal metabolism. We found that GSU increases progressively with age, independently of concomitant changes in renal function; significant correlations with biochemical markers of bone formation were also found. Therefore, the method appears to provide useful information concerning the bone turnover rate, and is also applicable to elderly people owing to its simplicity.

Key words

Bone turnover Global skeletal uptake Aging 

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References

  1. 1.
    Fogelman I, Bessent RG, Turner JG, Citrin DL, Boyle IT, Greig WR. The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease.J Nucl Med 1978; 19: 270–275.PubMedGoogle Scholar
  2. 2.
    Caniggia A, Vattimo A. Kinetics of 99m technetium-tin-methylene-diphosphonate in normal subjects and pathological conditions: a simple index of bone metabolism.Calcif Tissue Irct 1980; 30: 5–13.Google Scholar
  3. 3.
    D'Addabbo A, Rubini G, Mele M, Lauriero F. A new method for assessing 99Tc-m-MDP bone uptake from a bone scan image: quantitative measurement of radioactivity in global skeletal regions of interest.Nucl Med Commun 1992; 13: 55–60.PubMedGoogle Scholar
  4. 4.
    Rubini G, Lauriero F, Rubini D, D'Addabbo A. 99-Tc-mMDP global skeletal uptake and markers of bone metabolism in patients with bone diseases.Nucl Med Commun 1993, 14: 567–572.PubMedGoogle Scholar
  5. 5.
    Sorenson JA. Nuclear medicine tomography: principles. In: Sorenson JA, Phelps ME, eds. Physics in nuclear medicine. New York: Grune & Stratton; 1987: 391–423.Google Scholar
  6. 6.
    Goans RE, Abrams SA, Vieira NE, Marini JC, Perez MD, Yergey AL. A three-hour measurement to evaluate bone calcium turnover.Bone 1995; 16: 33–38.PubMedGoogle Scholar
  7. 7.
    Eastell R, Delmas PD, Hodgson SF, Eriksen EF, Mann KG, Riggs BL. Bone formation rate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers.J Clin Endocrinol Metab 1988; 67: 741–748.PubMedGoogle Scholar
  8. 8.
    Thomsen K, Johansen J. Nilas L, Christiansen C. Whole body retention of99mTc-diphosphonate. Relation to biochemical indices of bone turnover and to total body calcium.Eur J Nucl Med 1987; 13: 32–35.PubMedGoogle Scholar
  9. 9.
    Galasko CSB. The pathopbysiological basis for skeletal scintigraphy. In: Galasko CSB, Weber DA, eds. Radionuclide scintigraphy in orthopedics. Edinburgh: Churchill Livingstone; 1984; 34–53.Google Scholar
  10. 10.
    Sahni M, Guenther HL, Fleish H, Collin P, Martin J. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts.J Clin Invest 1993, 91: 2004–2011.PubMedGoogle Scholar
  11. 11.
    Hyldstrup L, Clemmensen I, Jensen BA, Transbol I. Noninvasive evaluation of bone formation: measurements of serum alkaline phosphatase, whole body retention of diphosphonate and serum osteocalcin in metabolic bone disorders and thyroid disease.Scand J Clin Lab Invest 1988; 48: 611–619.PubMedGoogle Scholar
  12. 12.
    Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment.J Clin Endocrinol Metab 1994; 79: 1693–1700.PubMedGoogle Scholar
  13. 13.
    Kanis JA. Treatment of osteoporosis in elderly women.Am J Med 1995; 98 Suppl 2A: 60S-66S.Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Vincenzo Carnevale
    • 1
  • Vincenzo Frusciante
    • 1
  • Alfredo Scillitani
    • 1
  • Sergio Modoni
    • 1
  • Mauro Pileri
    • 1
  • Iacopo Chiodini
    • 1
  • Franca Dicembrino
    • 1
  • Elisabetta Romagnoli
    • 2
  • Salvatore Minisola
    • 2
  1. 1.Ospedale “Casa Sollievo della Sofferenza”I.R.C.C.S. di San Giovanni RotondoFoggiaItaly
  2. 2.Istituto di II Clinica MedicaUniversità degli Studi di Roma “La Sapienza”RomeItaly
  3. 3.II Clinica MedicaPoliclinico Umberto 1RomeItaly

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