Formation of ribonucleoprotein particles by interaction of infectious viral RNA with cytoplasmic cell fractions

  • F. I. Yershov
  • V. M. Zhdanov
  • L. V. Uryvayev
Article
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Summary

Virus-specific RNA's interacting with various cytoplasmic cell fractions form ribonuclein particles. The sedimentation coefficients of ribonuclein particles vary from 60S to 80S and the buoyant density is 1.30 g/cm3 to 1.42 g/cm3. With respect to infectivity the particles formed by interaction of infectious virus RNA with cellular proteins behave like virions. However, they are only partially resistant to ribonuclease treatment and are not neutralized by virus-specific immune sera. This artificially produced phenomenon may reflect some events in virus replication.

Keywords

Infectious Disease Virus Replication Cellular Protein Cell Fraction Infectious Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • F. I. Yershov
    • 1
  • V. M. Zhdanov
    • 1
  • L. V. Uryvayev
    • 1
  1. 1.D. I. Ivanovsky Institute of VirologyMoscowUSSR

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