Journal of Neural Transmission

, Volume 36, Issue 3–4, pp 303–326

The potentiation of the anti akinetic effect after L-Dopa treatment by an inhibitor of Mao-B, deprenil

  • W. Birkmayer
  • P. Riederer
  • M. B. H. Youdim
  • W. Linauer
Article

Summary

The potentiation of the ami akinetic effect after L-Dopa treatment by an inhibitor of monoamine oxidase (MAO) “B”, Deprenil, has been demonstrated in parkinsonian patients with or without previous L-Dopa therapy. Application of the drug has been performed orally, intravenously and intramuscularly. Excellent kinetic effects resulted when combined with Madopar. The combined treatment with L-Dopa was highly effective when applicated i.v. or i.m.

Deprenil is an inhibitor of MAO-B and is characterized by less frequent side effects. These are predominantly involuntary movements and confusion, which can be eliminated by lowering the dosage of Deprenil.

A daily rhythm of MAO could be demonstrated in several areas of human brains as well in a control group as in parkinsonian patients with or without L-Dopa therapy. Maximal activity of MAO occurs between noon and 6 p.m.

The clinical and biochemical data are discussed regarding the off-phenomenons as Deprenil is an excellent drug for preventing these.

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • W. Birkmayer
    • 1
  • P. Riederer
    • 1
  • M. B. H. Youdim
    • 1
  • W. Linauer
    • 1
  1. 1.Ludwig-Boltzmann-Institut für NeurochemieGeriatrisches Krankenhaus der Stadt Wien-LainzAustria
  2. 2.MRC Clinical Pharmacology UnitRadcliffe InfirmaryOxfordGreat Britain
  3. 3.Evangelisches KrankenhausWien

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