MRI white matter hyperintensity in neuroleptic malignant syndrome (NMS)—a clue to pathogenesis?

  • T. Becker
  • J. Kornhuber
  • E. Hofmann
  • M. Weller
  • C. Rupprecht
  • H. Beckmann
Full Papers


The case of a young female patient with neuroleptic malignant syndrome (NMS) and extended MRI white matter hyperintensity in the left parietal and both occipital lobes is reported. MRI lesions resembled findings in hypertensive encephalopathy, they were not readily compatible with CNS vasculitis. Venous sinus thrombosis could be ruled out. Vascular encephalopathy with transient white matter edema and a small residual left parietal lesion is suggested. Neurochemical implications are discussed with particular reference to a possible involvement of excitatory amino acids in NMS pathogenesis.


Neuroleptic malignant syndrome magnetic resonance imaging white matter pathology venous sinus thrombosis vasculitis dopamine excitatory amino acids glutamate 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. Becker
    • 1
  • J. Kornhuber
    • 1
  • E. Hofmann
    • 2
  • M. Weller
    • 1
  • C. Rupprecht
    • 1
  • H. Beckmann
    • 1
  1. 1.Department of PsychiatryUniversity of WürzburgFederal Republic of Germany
  2. 2.Department of NeuroradiologyUniversity of WürzburgFederal Republic of Germany

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