Journal of Neural Transmission

, Volume 75, Issue 1, pp 1–10

3H-spiperone binding sites in post-mortem brains from schizophrenic patients: Relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms

  • J. Kornhuber
  • P. Riederer
  • G. P. Reynolds
  • H. Beckmann
  • K. Jellinger
  • E. Gabriel
Original Papers

Summary

In post-mortem putamen samples from 27 schizophrenics and 27 controls D2 receptors were measured by Scatchard analysis using3H-spiperone as a ligand. Maximum number of binding sites (Bmax) and apparent dissociation constant (KD) were significantly increased only in patients in whom neuroleptic medication had been given within a three-month period before death. When the neuroleptic medication had been withdrawn at least 3 month before death, there was a slight, but not significant, reduction in Bmax values and unchanged KD values. Withdrawal of neuroleptic drugs was followed by a normalization of the KD values within 2 weeks and a slower reduction of Bmax values. There were 6 schizophrenic patients with mainly positive schizophrenic symptoms and 17 patients with mainly negative symptoms; positive schizophrenic symptoms were not related to higher Bmax values. There was no difference in3H-spiperone binding between patients with and without movement disorders (tardive dyskinesia or extrapyramidal symptoms).

Keywords

D2 receptor schizophrenia spiperone tardive dyskinesia neuroleptic drugs 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • J. Kornhuber
    • 1
  • P. Riederer
    • 1
  • G. P. Reynolds
    • 2
  • H. Beckmann
    • 1
  • K. Jellinger
    • 3
  • E. Gabriel
    • 4
  1. 1.Department of PsychiatryUniversity of WürzburgGermany
  2. 2.Department of PathologyUniversity of NottinghamNottinghamUK
  3. 3.Ludwig Boltzmann Institute for Clinical NeurobiologyVienna
  4. 4.Baumgartner Psychiatric HospitalViennaAustria

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