Journal of Neural Transmission

, Volume 47, Issue 3, pp 153–161 | Cite as

CNS tryptamine metabolism in hepatic coma

  • S. N. Young
  • S. Lal


Lumbar CSF indoleacetic acid (IAA) was higher in patients with cirrhosis of the liver than in controls. It was also higher in CSF of patients in coma than in those with hepatic cirrhosis but not in coma. There was a strong correlation (r=0.89, p<0.01) between the grade of hepatic coma and CSF IAA. These data indicate that there is an association between elevated CNS tryptamine metabolism and hepatic coma. How far changes in the metabolism of tryptamine and other trace amines are relevant to the induction of hepatic coma or are simply a reflection of advanced liver dysfunction is unclear.


Public Health Strong Correlation Liver Dysfunction Indoleacetic Acid Tryptamine 
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • S. N. Young
    • 1
  • S. Lal
    • 1
  1. 1.Department of PsychiatryMcGill UniversityMontrealCanada

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