Archiv für die gesamte Virusforschung

, Volume 35, Issue 2–3, pp 183–193 | Cite as

Zika virus infection of the central nervous system of mice

  • T. M. Bell
  • E. J. Field
  • H. K. Narang
Article

Summary

Intracerebral inoculation of newborn and 5-week-old mice with Zika virus resulted in an early and marked enlargement of astroglial cells with patchy destruction of the pyriform cells of Ammon's horn. Replication of the virus was demonstrated in both neurones and astroglial cells. New virions appeared to be formed within networks of endoplasmic reticulum. The similarity of these ultrastructural observations to those obtained fromin vivo studies of other group B arboviruses is contrasted with the widely differing findings fromin vitro studies.

References

  1. 1.
    Dick, G. W. A., S. F. Kitchen, andA. J. Haddow: Zika Virus. (1) Isolations aiid serological specificity. Trans. roy. Soc. trop. Med. Hyg.46, 509–520 (1952).Google Scholar
  2. 2.
    Weinbren, M. P., andM. C. Williams: Zika Virus: Further isolations in the Zika area, and some studies on the strains isolated. Trans. roy. Soc. trop. Med. Hyg.52, 263–268 (1964).Google Scholar
  3. 3.
    Woodall, J. P.: The viruses isolated from arthropods at the East African Virus Research Institute in the 26 years ending December 1963. Proc. E. Afr. Acad.2, 141–146 (1964).Google Scholar
  4. 4.
    Haddow, A. J., M. C. Williams, J. P. Woodall, D. I. H. Simpson, andL. K. H. Goma: Twelve isolations of Zika virus fromAedes (Stegomyia) africanus (Theobald) taken in and above a Uganda forest. Bull. Wld Hlth Org.31, 57–69 (1964).Google Scholar
  5. 5.
    Dick, G. W. A.: Zika virus. (II). Pathogenicity and physical properties. Trans. roy. Soc. trop. Med. Hyg.46, 521–534 (1952).Google Scholar
  6. 6.
    Bell, T. M., H. K. Narang, andE. J. Field: Influenzal encephalitis in mice: A histopathological and electron microscopical study. Arch. ges. Virusforsch.34, 158–167 (1971).Google Scholar
  7. 7.
    Zlotnik, I.: The reaction of astrocytes to acute virus infections of the central nervous system. Brit. J. exp. Path.49, 555–564 (1969).Google Scholar
  8. 8.
    Rook, G. A. W., andH. E. Webb: Antilymphocyte serum and tissue culture used to investigate role of cell-mediated response in viral encephalitis in mice. Brit. med. J.4, 210–212 (1970).Google Scholar
  9. 9.
    Yasuzumi, G., I. Tsubo, R. Sugihasa, andY. Nakai: Analysis of the development of Japanese B encephalitis (JBE) virus. I. Electron microscopic studies of microglia infected with JBE virus. J. Ultrastruct. Res.11, 213–229 (1964).Google Scholar
  10. 10.
    Oyanagi, S., F. Ikuta, andE. R. Ross: Electron microscopic observations in mice infected with Japanese encephalitis. Acta neuropath. (Berl.)13, 169–181 (1964).Google Scholar
  11. 11.
    Blinzinger, K., undW. Muller: Elektronenmikroskopische Beobachtung des Virus der Frühsommer-Meningo-encephalitis (Stamm HYPR) in Nervenzellen von experimentell infizierten Albinomäusen. Dtsch. Z. Nervenheilk.197, 18–27 (1970).Google Scholar
  12. 12.
    Peat, A., andT. M. Bell: Entebbe bat salivary gland virus: Electron microscopic study of morphology and development in newborn mice. Arch. ges. Virusforsch.31, 230–236 (1970).Google Scholar
  13. 13.
    Williams, M. C., D. I. H. Simpson, R. C. Shepherd, J. P. O'Sullivan, J. C. Cunningham, andM. Lule: Virus isolation from bats. Rep. E. Afr. Virus Res. Inst.14, 42 (1965).Google Scholar
  14. 14.
    Filshie, B. K., andJ. Rehacek: Studies on the morphology of Murray Valley encephalitis and Japanese encephalitis growing in cultured mosquito cells. Virology34, 435–443 (1968).Google Scholar
  15. 15.
    Ota, Z.: Electron microscopic study of the development of Japanese B encephalitis virus in porcine kidney stable (PS) cells. Virology25, 372–378 (1965).Google Scholar
  16. 16.
    Parker, J. R., andL. M. Stannard: Intracytoplasmic inclusions in foetal lamb kidney cells infected with Wesselsbron virus. Arch. ges. Virusforsch.20, 469–472 (1967).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • T. M. Bell
    • 1
  • E. J. Field
    • 1
  • H. K. Narang
    • 1
  1. 1.Medical Research Council, Demyelinating Diseases UnitNewcastle General HospitalNewcastle upon TyneEngland

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