Archiv für die gesamte Virusforschung

, Volume 35, Issue 2–3, pp 183–193 | Cite as

Zika virus infection of the central nervous system of mice

  • T. M. Bell
  • E. J. Field
  • H. K. Narang


Intracerebral inoculation of newborn and 5-week-old mice with Zika virus resulted in an early and marked enlargement of astroglial cells with patchy destruction of the pyriform cells of Ammon's horn. Replication of the virus was demonstrated in both neurones and astroglial cells. New virions appeared to be formed within networks of endoplasmic reticulum. The similarity of these ultrastructural observations to those obtained fromin vivo studies of other group B arboviruses is contrasted with the widely differing findings fromin vitro studies.


Ammon Nervous System Central Nervous System Infectious Disease Endoplasmic Reticulum 
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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • T. M. Bell
    • 1
  • E. J. Field
    • 1
  • H. K. Narang
    • 1
  1. 1.Medical Research Council, Demyelinating Diseases UnitNewcastle General HospitalNewcastle upon TyneEngland

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