The effects of antidepressants on the autonomic nervous system-a current investigation
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Tricyclic antidepressants influence the autonomic nervous system, as is well known; and endogenous depression shows autonomie nervous symptoms besides the readily observable emotional changes. This is a report on a current investigation of the effects of antidepressants on the function of the autonomie nervous system.
In the amitriptyline group, the spontaneous SPR and serum DBH activity decreased, and heart rate increased; and the degree of change before and after administration of the drug was statistically significant. Thus amitriptyline seems to suppress the activity of sympathetic nervous system, in addition to suppressing the functioning of the parasympathetic nervous system.
In the nomifensine group, spontaneous SPR and serum DBH activity tended to increase. This seems to indicate that nomifensine suppresses neither the parasympathetic nor the sympathetic nervous functions.
Amitriptyline and nomifensine has different effects on the sympathetic nervous system, suggesting correspondingly divergent pharmacological mechanisms for the depressive modality.
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