Journal of Neural Transmission

, Volume 49, Issue 1–2, pp 133–135

Electroconvulsive therapy in Parkinsonian patients with the “on-off” syndrome

  • C. Ward
  • G. M. Stern
  • R. T. C. Pratt
  • Pat McKenna
Short Communications

DOI: 10.1007/BF01249195

Cite this article as:
Ward, C., Stern, G.M., Pratt, R.T.C. et al. J. Neural Transmission (1980) 49: 133. doi:10.1007/BF01249195

Summary

Marked, abrupt and disabling oscillations in motor performance—the “on-off” phenomenon-frequently occur in the course of long-term levo-dopa therapy for Parkinson's disease. Although these fluctuations are usually refractory to available medications it has recently been suggested that electroconvulsive therapy (ECT) may be beneficial.

Five Parkinsonian patients with incapacitating and unpredictable “on-off” changes who were free of significant depression were given conventional bilateral ECT while usual drug regimens were maintained. While ECT was well tolerated, after a total of six treatments no significant improvement in Parkinsonian disabilities or “on-off” changes were seen.

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • C. Ward
    • 1
    • 2
  • G. M. Stern
    • 1
    • 2
  • R. T. C. Pratt
    • 1
    • 2
  • Pat McKenna
    • 1
    • 2
  1. 1.University College HospitalLondon
  2. 2.The National Hospital for Nervous DiseasesLondonUK

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