Intestinal absorption of fat
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Summary
It is generally accepted that between 50 and 70% of the fatty acids of ingested triglycerides are hydrolyzed prior to absorption and yet migration between the 2 and 1,3 positions is minimal. The occurrance of the monoglyceride pathway for triglyceride biosynthesis provides a logical explanation for these findings. In addition, this sequence provides a logical explanation of the “particulate” and “lipolytic” theories. Triglycerides are hydrolyzed at the 1 and 3 positions giving rise to fatty acids and 2-monoglycerides, which in combination with bile salts form micelles and penetrate the intestinal membrane. The fatty acids are activated to the respective CoA derivatives and acylate the 2-monoglyceride forming triglycerides. The triglyceride thus synthesized, has a similar chemical structure with regard to the 1,3 and 2 position as the original triglyceride. The triglyceride is coated with aβ-lipoprotein and is transformed into chylomicrons which enter the thoracic duct lymph.
It is suggested that this mechanism be referred to as the “PARLIP” sequence since, particles in the form of micelles are involved in the absorption, and in addition a considerable amount of lipolysis occurs. This terminology would represent a scientific merger of the particulate and the lipolytic theories into a common sequence, while maintaining some identity in recognition of the numerous investigations that have occurred in the past 100 years to support these two basic postulates.
Keywords
Triglyceride Bile Salt Numerous Investigation Intestinal Absorption Similar ChemicalPreview
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