Journal of Neural Transmission

, Volume 45, Issue 4, pp 273–284 | Cite as

Norepinephrine turnover in pineal gland and superior cervical ganglia. Changes after gonadotrophin administration to castrated rats

  • D. P. Cardinali
  • María I. Vacas


The effects of FSH and LH on norepinephrine (NE) turnover in pineal gland and superior cervical ganglia of castrated female rats were examined by measuring the decline of [3H]NE concentration in the organ 30–120 min after a single i.v. injection of the labeled amine. Both FSH and LH treatment significantly decreased [3H]NE turnover in the pineal gland whereas only FSH accelerated it in the ganglia. As compared to controls, the initial uptake of [3H]NE was lower in the pineal gland of FSH- and LH-treated animals, and higher in the superior cervical ganglia of rats injected with FSH. Neither FSH nor LH modified [3H]NE turnover in heart or adrenal gland, nor changed their endogenous catecholamine content. Pineal monoamine oxidase (MAO) activity type B (assaying by usingβ-phenylethylamine as substrate) was decreased by FSH or LH injection. Only FSH modified MAO activity in the ganglia by increasing significantly type A enzyme (assaying by using serotonin as substrate). These results suggest that FSH and LH affect significantly NE metabolism in pineal gland and superior cervical ganglia of spayed rats.

Key words

FSH LH pineal gland superior cervical ganglion norepinephrine metabolism 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • D. P. Cardinali
    • 1
    • 2
  • María I. Vacas
    • 1
    • 3
  1. 1.Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN)Buenos AiresArgentina
  2. 2.Consejo Nacional de Investigaciones Científicas y TécnicasArgentina
  3. 3.Consejo Nacional de Investigaciones Científicas y TécnicasArgentina

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