Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)

  • J. Staedt
  • G. Stoppe
  • A. Kögler
  • D. Munz
  • H. Riemann
  • D. Emrich
  • E. Rüther
Short Communication

Summary

Periodic movements in sleep (PMS) can cause severe sleep disturbances. We investigated the central dopamine D2 receptor density in patients with PMS with123I-IBZM and single photon emission tomography (SPET). In PMS there was a lower123I-IBZMbinding in the basal ganglia compared tothe control group. The results indicate a loss of central D2 receptors in PMS.

Keywords

Dopamine receptors octurnal myoclonus PMS SPET 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • J. Staedt
    • 1
  • G. Stoppe
    • 1
  • A. Kögler
    • 2
  • D. Munz
    • 2
  • H. Riemann
    • 1
  • D. Emrich
    • 2
  • E. Rüther
    • 1
  1. 1.Department of PsychiatryGeorg August UniversityGöttingenFederal Republic of Germany
  2. 2.Department of Nuclear MedicineGeorg August UniversityGöttingenFederal Republic of Germany

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