Orcadian variations of superoxide dismutase activity in the rat pineal gland

  • J. Cipolla-Neto
  • D. S. P. Abdalla
  • R. P. Markus
  • A. Campa
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Summary

The 24 h profile of the activity of the antioxidant enzyme Superoxide dismutase (SOD) in the pineal gland of rats was studied. Rhythmic analysis showed a significant 24 h rhythm with an amplitude of oscillation of 25% of the 24 h mean value, that was 100.34±1.6 U SOD (nitrite). An ultradian rhythm of 9 h was also detected. The diurnal profile of Superoxide dismutase activity is discussed in relation to the oxidative metabolism of the pineal gland.

Keywords

Superoxide dismutase pineal gland circadian variations 
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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • J. Cipolla-Neto
    • 1
  • D. S. P. Abdalla
    • 2
  • R. P. Markus
    • 3
  • A. Campa
    • 2
  1. 1.Department of Physiology and BiophysicsInstitute de Ciências BiomédicasBrazil
  2. 2.Department of Clinical ChemistryFaculdade de Ciências FarmacêuticasBrazil
  3. 3.Department of Pharmacology, Instituto de Ciências BiomédicasUniversidade de São PauloSão PauloBrazil

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