The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer

  • J. Hyttel
  • K. P. Bøgesø
  • J. Perregaard
  • C. Sánchez
Short Communication

DOI: 10.1007/BF01244820

Cite this article as:
Hyttel, J., Bøgesø, K.P., Perregaard, J. et al. J. Neural Transmission (1992) 88: 157. doi:10.1007/BF01244820

Summary

The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N-demethylcitalopram very much resembles the profile of the respective racemates.

Keywords

Citalopram enantiomers 5-HT uptake 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. Hyttel
    • 1
  • K. P. Bøgesø
    • 1
  • J. Perregaard
    • 1
  • C. Sánchez
    • 1
  1. 1.Research & DevelopmentH. Lundbeck A/SCopenhagenDenmark

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