Effects of sertraline and citalopram given repeatedly on the responsiveness of 5-HT receptor subpopulations

  • J. Maj
  • E. Moryl
Full Papers

DOI: 10.1007/BF01244819

Cite this article as:
Maj, J. & Moryl, E. J. Neural Transmission (1992) 88: 143. doi:10.1007/BF01244819


The effect of repeated treatment (5 and 10 mg/kg,po, twice daily, 14 days) with sertraline and citalopram (antidepressants which selectively inhibit the reuptake of 5-hydroxytryptamine (5-HT)) on the responsiveness of different 5-HT receptors to their agonists, was examined in rats and mice. Sertraline and citalopram (both at a dose 5 and 10 mg/kg) antagonized (the first one more potently) the hypothermia induced in mice by 8-OH-DPAT (a 5-HT1A agonist), but not the behavioural syndrome induced in rats by this substance. The m-chlorophenylpiperazine-induced hypothermia in mice (a 5-HT1B effect) was increased by sertraline and citalopram (only in a dose of 10 mg/kg). Both antidepressants, given repeatedly (as well acutely) attenuated exploratory hypoactivity induced in rats by m-chlorophenylpiperazine (a 5-HT1C effect). L-5-HTP-induced head twitches in mice (5-HT2 effect) were antagonized dose-dependently by both repeated sertraline and citalopram. Both antidepressants (citalopram only in higher dose) reduced the fenfluramine-induced hyperthermia in rats (5-HT2 effect).

The results indicate that sertraline and citalopram given repeatedly decrease the responsiveness of 5-HT1A (presynaptic) and 5-HT2 receptors but increase the responsiveness of 5-HT1B receptors to respective agonists.


Antidepressants 5-HT receptor subpopulations mice rats 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. Maj
    • 1
  • E. Moryl
    • 1
  1. 1.Institute of PharmacologyPolish Academy of SciencesKrakówPoland

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