Journal of Neural Transmission

, Volume 73, Issue 2, pp 129–134 | Cite as

Gabapentin augments whole blood serotonin in healthy young men

  • Marie Luise Rao
  • P. Clarenbach
  • M. Vahlensieck
  • S. Krätzschmar
Original Papers


It has been previously demonstrated that gabapentin, a gamma-amino butyric acid analogue, inhibits monoaminergic neurotransmitter release from rabbit caudate nucleus slices and from rat cortex. In humans this drug has been shown to have anti-epileptogenic activity. Serotonin may act as an inhibitory neurotransmitter and its interaction with blood platelets is thought to reflect its central actions. We investigated sleep stages, whole blood serotonin levels, and serum melatonin in healthy men after the administration of gabapentin. With increasing serum gabapentin levels six healthy subjects showed an increase in sleep stages 3 and 4 and in whole blood serotonin (P<0.05). Serum melatonin levels were not influenced.

On account of these results we speculate that gabapentin modulates the release of serotonin from blood platelets. The increase in peripheral serotonin points paradigmatically to an increase in the bioavailability of serotonin which may account for the increase in sleep stages 3 and 4.


Gabapentin gaba-analogue sleep pattern human whole blood serotonin level nocturnal serum melatonin profile 


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Copyright information

© Springer Verlag 1988

Authors and Affiliations

  • Marie Luise Rao
    • 1
  • P. Clarenbach
    • 2
  • M. Vahlensieck
    • 1
  • S. Krätzschmar
    • 2
  1. 1.Department of Psychiatry, Nervenklinik und PoliklinikUniversität BonnBonnGermany
  2. 2.Department of Neurology, Nervenklinik und PoliklinikUniversität BonnBonnGermany

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