Archiv für die gesamte Virusforschung

, Volume 11, Issue 4, pp 599–606

On the structure of filamentous forms of influenza virus

  • I. Archetti
  • D. Steve Bocciarelli
Article

Conclusions and Summary

The observation of two filamentous strains of influenza A viruses shows that filaments present a surface structure identical to that of spheres, as already observed byChoppin et al. (3). This outer shell is comprised of dumb-bell shaped subunits (80 Å from axis to axis). The diameter of each small grain of the dumb-bell is about 30 A and they are about 25 Å apart. As is clearly seen in the sections, these subunits are supported by a continuous membrane, as already suggested byMorgan et al. (1) and byHoyle et al. (8).

In the cross section of the filaments, an internal material is also revealed; this seems to be unevenly distributed along the filament and appears to be constituted of ordered little grains, 50 Å in diameter. This material is dissimilar to that observed in the spheres, in which it has the appearance of very thin threads, about 25 Å thick. The frequent presence of septa (in about 25% of filaments) can be clearly seen. Sometimes, instead of septa, a regular succession of constrictions is observed, which is in keeping with the hypothesis that some of the spheres are formed from the filaments by a process of segmentation.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Morgan, C., H. M. Rose, D. H. Moore: J. Exp. Med.104, 171 (1956).PubMedGoogle Scholar
  2. 2.
    Horne, R. W., A. P. Waterson, P. Wildy, A. E. Farnham: Virology11, 79 (1960).PubMedGoogle Scholar
  3. 3.
    Choppin, P. W., T. S. Murphy, W. Stoeckenius: Virology13, 548 (1961).PubMedGoogle Scholar
  4. 4.
    Archetti, I., D. Steve Bocciarelli, G. Toschi, andA. Violante: III° Congresso Italiano di Microscopia Elettronica: Milano 3–4 Milan 1961, in press.Google Scholar
  5. 5.
    Burnet, F. M., P. E. Lind: Archiv f. Virusforschung7, 413 (1957).Google Scholar
  6. 6.
    Brenner, S., R. W. Horne: Biochem. et Biophys. Acta34, 103 (1959).Google Scholar
  7. 7.
    Archetti, I.: Archiv f. Virusforschung6, 29 (1955).Google Scholar
  8. 8.
    Hoyle, L., R. W. Horne, A. P. Waterson: Virology13, 448 (1961).PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1962

Authors and Affiliations

  • I. Archetti
    • 1
  • D. Steve Bocciarelli
    • 1
  1. 1.Laboratori di Microbiologia e di FisicaIstituto Superiore di SanitàRoma

Personalised recommendations