Virchows Archiv A

, Volume 364, Issue 2, pp 179–190 | Cite as

“Killer”-lymphocytes in action?

Light and electron microscopical findings in orthotopic liver homografts
  • L. Cossel
  • P. -F. Mahnke
  • R. Schwarzer
Article
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Summary

Light and electron microscopical findings in orthotopic porcine liver homografts showing small, clear lymphocytes in close contact with circumscribed cell membrane defects, partial lysis, and lytic single cell necroses of liver epithelial cells are described and demonstrated. The interpretation of these results obtained ‘in vivo’ by the examination of tissue during the host-versus-graft reaction as an equivalent of the cytopathogenetic activity of immunologically activated lymphocytes (“killer”-lymphocytes) causing lysis of target cells, which has been determined by ‘in vitro’ observation of tissue cultures, is discussed.

Keywords

Public Health Cell Membrane Epithelial Cell Tissue Culture Single Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • L. Cossel
    • 1
  • P. -F. Mahnke
    • 1
  • R. Schwarzer
    • 1
  1. 1.Institute of PathologyKarl-Marx-UniversityLeipzig

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