Archives of Toxicology

, Volume 54, Issue 3, pp 203–213

Neurotoxicity of acrylamide and related compounds in rats

Effects on rotarod performance, morphology of nerves and neurotubulin
  • Hideji Tanii
  • Kazuo Hashimoto
Original Investigations

DOI: 10.1007/BF01239204

Cite this article as:
Tanii, H. & Hashimoto, K. Arch Toxicol (1983) 54: 203. doi:10.1007/BF01239204


Neurotoxic properties of acrylamide and seven related compounds in rats were studied with regard to the effects on rotarod performance, morphology of nerves and neurotubulin. Compounds used in the present study were acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N-methylacrylamide, crotonamide, diacetone acrylamide, and N-tert-butylacrylamide. Animals were given chemicals in their drinking water for 90 days. Deficit of rotarod performance was produced by five compounds; acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, and N-methylacrylamide. Morphological changes in tibial and sural nerves, such as shrinkage and loss of myelinated fibres, myelin retraction, and corrugated myelin sheaths, were observed after treatment with these five compounds. Depression of the [3H]colchicinebinding to neurotubulin (the soluble protein) of sciatic nerves was detected after giving these five compounds. After acrylamide dosing, the depression progressed with time. A significant reduction of the colchicine-binding to neurotubulin was also detected in the spinal cord of both the cervical and the lumbar regions, but neither in the brain nor the cerebellum.

Key words

Acrylamide analogues Acrylamide N-tert-Butylacrylamide Crotonamide Diacetone acrylamide N-Hydroxymethylacrylamide N-Isopropylacrylamide Methacrylamide N-Methylacrylamide Neurotoxicity Rotarod performance Histopathology Neurotubulin Rat 

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Hideji Tanii
    • 1
  • Kazuo Hashimoto
    • 1
  1. 1.Department of HygieneSchool of Medicine, Kanazawa UniversityIshikawaJapan

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