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Somatic Cell and Molecular Genetics

, Volume 17, Issue 6, pp 609–615 | Cite as

The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

  • Penny Williamson
  • Jill Lang
  • Yvonne Boyd
Brief Communication

Abstract

The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine homolog ofLHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.

Keywords

Somatic Cell Human Chromosome Cell Hybrid Homologous Region Mouse Chromosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Penny Williamson
    • 1
  • Jill Lang
    • 2
  • Yvonne Boyd
    • 1
  1. 1.Genetics Division (Harwell), MRC Radiobiology UnitChilton, DidcotEngland
  2. 2.Department of Human Anatomyuniversity of OxfordOxfordEngland

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