Somatic Cell and Molecular Genetics

, Volume 19, Issue 6, pp 571–575

The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus

  • Takahiko Hara
  • Masatake Yamauchi
  • Ei-ichi Takahashi
  • Masato Hoshino
  • Kazuhisa Aoki
  • Dai Ayusawa
  • Masao Kawakita
Brief Communication

Abstract

We have cloned a segment of the human gene encoding UDP-galactose translocator by genetic complementation of its defective mutant in mouse FM3A cells. Chromosome mapping using fluorescentin situ hybridization revealed that the cloned gene hybridized to the Xp11.23-11.23 region of the X chromosome. This region is shared by the locus of Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency disorder, characterized by defective sugar chains on cell surface components. Genetic and phenotypic similarities suggest a possible link between UDP-galactose translocator and the Wiskott-Aldrich syndrome (WAS).

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Takahiko Hara
    • 1
  • Masatake Yamauchi
    • 2
  • Ei-ichi Takahashi
    • 2
  • Masato Hoshino
    • 1
  • Kazuhisa Aoki
    • 1
  • Dai Ayusawa
    • 3
  • Masao Kawakita
    • 1
  1. 1.Department of Pure and Applied Sciences, College of Arts and SciencesUniversity of TokyoTokyoJapan
  2. 2.Division of GeneticsNational Institute of Radiological SciencesChibaJapan
  3. 3.Institute of Molecular and Cellular BiosciencesUniversity of TokyoTokyoJapan
  4. 4.DNAX Research Institute of Molecular and Cellular Biology, Inc.Palo Alto

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