Somatic Cell and Molecular Genetics

, Volume 17, Issue 5, pp 519–523

Tumor necrosis factor receptor genes,TNFR1 andTNFR2, on human chromosomes 12 and 1

  • A. Milatovich
  • K. Song
  • R. A. Heller
  • U. Francke
Brief Communication

DOI: 10.1007/BF01233176

Cite this article as:
Milatovich, A., Song, K., Heller, R.A. et al. Somat Cell Mol Genet (1991) 17: 519. doi:10.1007/BF01233176

Abstract

Tumor necrosis factor, TNF, is a 17-kDa protein secreted by macrophages and classified as a cytokine. TNF binds to high-affinity receptors on the cell surface and is involved in a wide variety of biological responses. There are at least two types of receptors, tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2). The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 1 12 (12pter-cen) and (1pter-p32), respectively, by Southern blot analysis of human × Chinese hamster somatic cell hybrid panels. Recently, the corresponding genes in the mouse have been mapped to chromosomes 4 and 6 in regions that are conserved on human chromosomes 1 and 12.

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • A. Milatovich
    • 1
  • K. Song
    • 3
  • R. A. Heller
    • 3
  • U. Francke
    • 1
    • 2
  1. 1.Department of GeneticsStanford University School of MedicineStanford
  2. 2.Howard Hughes Medical InstituteStanford University School of MedicineStanford
  3. 3.Institute of Cancer and Developmental Biology, Syntex ResearchPalo Alto

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