Somatic Cell and Molecular Genetics

, Volume 17, Issue 2, pp 207–214 | Cite as

Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter

  • Edwin N. Geissler
  • Martha Liao
  • J. David Brook
  • Francis H. Martin
  • Krisztina M. Zsebo
  • David E. Housman
  • Stephen J. Galli
Brief Communication


Recently a novel hematopoietic growth factor, stem cell factor (SCF), was cloned and demonstrated to be the ligand for the c-kit tyrosine kinase receptor. In the mouse, SCF is encoded bySl (steel), a gene critical to the development of several distinct cell lineages during embryonic life and which has important effects on hematopoiesis in the adult animal. TheS1/SCF locus maps to the distal region of mouse chromosome 10, in the vicinity of genes that have been mapped to human chromosome 12. Here we report the use of somatic cell hybrid lines to localizeSCF to the long arm of human chromosome 12, between 12q14.3 and 12qter. In addition to localizing theSl homolog in man, these data provide further evidence for the conservation of synteny between the long arm of human chromosome 12 and the distal end of mouse chromosome 10.


Tyrosine Somatic Cell Tyrosine Kinase Receptor Human Chromosome Adult Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    Martin, F.H., Suggs, S.V., Lu, H., Johnson, M.J., Okino, K., Parker, V., Langley, K., Morris, F., McNiece, I., Jacobsen, F.W., Flores, J., Patel, A., Birkett, N., Smith, K., Mendiaz, E., Wypych, W., Sachdev, R., Pope, J. and Zsebo, K. (1990).Cell 63203–211.Google Scholar
  2. 2.
    Zsebo, K.M., Wypych, J., McNiece, I.K., Lu, H.S., Smith, K., Karkare, S., Sachdev, R., Yuschenkoff, V., Birkett, N., Williams, L., Satyagal, V., Mendiaz, E.A. and Langley, K.E. (1990).Cell 63195–201.Google Scholar
  3. 3.
    Geissler, E.N., Ryan, M.A., and Housman, D. (1988).Cell 55185–192.Google Scholar
  4. 4.
    Zsebo, K., Williams, D.A., Geissler, E.N., Broudy, V.C., Martin, F.H., Hsu, R-Y., Birkett, N., Okino, K.H., Murdock, D., Jacobsen, F.W., Langley, K.E., Smith, K.A., Takeishi, T., Cattanach, B.M., Galli, S.J., and Suggs, S.V. (1990).Cell 63213–224.Google Scholar
  5. 5.
    Williams, D.E., Eisenman, J., Baird, A., Rauch, C., Van Ness, K., March, C.J., Park, L.S., Martin, U., Mochizuki, D.Y., Boswell, H.S., Burgess, G.S., Cosman, D., Anderson, D., Lyman, S.D. and Williams, D.E. (1990).Cell 63167–174.Google Scholar
  6. 6.
    Copeland, N.G., Gilbert, D.J., Cho, B.C., Donovan, P.J., Jenkins, N.A., Cosman, D., Anderson, D., Lyman, S.D., and Williams, D.E. (1990).Cell 63175–183.Google Scholar
  7. 7.
    Flanagan, J.G., and Leder, P. (1990).Cell 63185–194.Google Scholar
  8. 8.
    Huang, E., Nocka, K., Beier, D.R., Chu, T.-Y., Buck, J., Lahm, H.-W., Wellner, D., Leder, P., and Besmer, P. (1990).Cell 63225–233.Google Scholar
  9. 9.
    Anderson, D.M., Lyman, S.D., Baird, A., Wignall, J.M., Eisenman, J., Rauch, C., March, C.J., Boswell, H.S., Gimpel, S.D., Cosman, D., and D.E. Williams (1990).Cell 63235–243.Google Scholar
  10. 10.
    Russell, E.S. (1979).Adv. Genet. 20357–459.Google Scholar
  11. 11.
    Silvers, W.K. (1979). InThe Coat Colors of Mice: A Model for Gene Action and Interaction (Springer-Verlag, New York), pp. 206–241.Google Scholar
  12. 12.
    Kitamura, Y., Nakayama, H., and Fujita, J. (1989). InMast Cell and Basophil Differentiation and Function in Health and Disease (eds.) Galli, S.J., and Austen, K.F. (Raven Press, New York), pp. 229–246.Google Scholar
  13. 13.
    Kitamura, Y. (1979).Blood 53492–497.Google Scholar
  14. 14.
    Yarden, Y., Kuang, W., Yang-Feng, T., and Ullrich, A. (1987).EMBO J. 63341–3351.Google Scholar
  15. 15.
    Qiu, F., Ray, P., Brown, K., Barker, P.E., Jhanwar, S., Ruddle, F.H., and Besmer, P. (1988).EMBO J. 71003–1011.Google Scholar
  16. 16.
    Andre, C., Auriol, L., Lacombe, C., Gisselbrecht, S., and Galibert, F. (1989).Oncogene 41047–1049.Google Scholar
  17. 17.
    Tan, J.C., Nocka, K., Ray, P., Traktman, P., and Besmer, P. (1990).Science 247209–212.Google Scholar
  18. 18.
    Reith, A.D., Rottapel, R., Giddens, E., Brady, C., Forrester, L., and Bernstein, A. (1990).Genes Dev. 3390–400.Google Scholar
  19. 19.
    Nocka, K., Majumder, S., Chabot, B., Ray, P., Cervone, M., Bernstein, A., and Besmer, P. (1989).Genes Dev. 3816–826.Google Scholar
  20. 20.
    Nocka, K., Tan, J.C., Chiu, E., Chu, T.Y., Ray, P., Traktman, P., and Besmer, P. (1990).EMBO J. 9180–1813.Google Scholar
  21. 21.
    Orr-Urtreger, A., Avivi, A., Zimmer, Y., Givol, D., Yarden, Y., and Lonai, P. (1990).Development 109911–923.Google Scholar
  22. 22.
    Bernstein, S.E. (1970).Am. J. Surg. 119448–451.Google Scholar
  23. 23.
    Lyon, M.F., and Kirby, M.C. (1990).Mouse News Lett. 8728–50.Google Scholar
  24. 24.
    Ropers, H.-H., and Craig, I.W. (1989).Cytogenet. Cell Genet. (Human Gene Mapping 10) 51259–279.Google Scholar
  25. 25.
    Lalley, P.A., Davidson, M.T., Graves, J.A., O'Brien, S.J., Womack, J.E., Roderick, T.H., Creau-Goldberg, N., Hillyard, A.L., Doolittle, D.P., and Rogers, J.A. (1989).Cytogenet. Cell Genet. 51503–532.Google Scholar
  26. 26.
    Nadeau, J., Grant, P., and Kosowsky, M. (1990).Mouse News Lett. 8755–60.Google Scholar
  27. 27.
    NIGMS Human Genetic Mutant Cell Repository. (1988–1989). Catalog of Cell Lines, NIH Publication No. 89-2011, Rev Oct 1988.Google Scholar
  28. 28.
    Brook, J.D., Beresford, H.R., Show, D.J., and Rettig, W.J. (1987).Cytogenet. Cell Genet. 4130–37.Google Scholar
  29. 29.
    Lugo, T.G., Handelin, B., Killary, A.M., Housman, D.E., and Fournier, R.E.K. (1987).Mol. Cell. Biol. 72814–2820.Google Scholar
  30. 30.
    Gusella, J., Varsanyi-Breiner, A., Kao, F., Jones, C., Puck, T., Keys, C., Orkin, S., and Housman, D. (1979).Proc. Natl. Acad. Sci. U.S.A. 765239–5243.Google Scholar
  31. 31.
    Athwal, R.S., Smarsh, M., Searle, B.M., and Deo, S.S. (1985).Somat. Cell Mol. Genet. 11177–187.Google Scholar
  32. 32.
    Carlock, L.R., Skarecky, D., Dana, S.L., and Wasmuth, J.J. (1985).Am. J. Hum. Genet. 371839–1852.Google Scholar
  33. 33.
    Carlock, L.R., Smith, D., and Wasmuth, J.J. (1986).Somat. Cell Mol. Genet. 11163–174.Google Scholar
  34. 34.
    VanKeuren, M.L., Watkins, P.C., Drabkin, H.A., Jabs, E.W., Gusella, J.F., and Patterson, D. (1986).Am. J. Hum. Genet. 38793–804.Google Scholar
  35. 35.
    Arfin, S.M., Cirullo, R.E., Arrendondo-Vega, F.X., and Smith, M. (1983).Somat. Cell Genet. 9517–531.Google Scholar
  36. 36.
    Van Tuinen, P., Rich, D.C., Summers, K.M., and Ledbetter, D.H. (1987).Genomics 1374–381.Google Scholar
  37. 37.
    MacDonald, M.E., Anderson, M.A., Gilliam, T.C., Tranejaerg, L., Carpenter, N.J., Magenis, E., Hayden, M.R., Healey, S.T., Bonner, T.I., and Gusella, J.F. (1987).Genomics 129–34.Google Scholar
  38. 38.
    Mascarello, J.T., Soderberg, K., and Scheffler, I.E. (1980).Cytogenet. Cell Genet. 28121–135.Google Scholar
  39. 39.
    Patterson, D., Gardiner, K., Kao, F.T., Tanzi, R., Watkins, P. and Gusella, J. (1988).Proc. Natl. Acad. Sci. U.S.A. 858266–8270.Google Scholar
  40. 40.
    Faber, H.E., Kucherlaptai, R.S., Poulik, M.D., Ruddle, F.H., and Smithies, O. (1976).Somat. Cell Genet. 2141–153.Google Scholar
  41. 41.
    Warburton, D., Gersen, S., Yu, M.-T., Jackson, C., Handelin, B., and Housman, D. (1990).Genomics 6358–366.Google Scholar
  42. 42.
    Callen, D.F. (1986).Ann. Genet. 29235–239.Google Scholar
  43. 43.
    Van Keuren, M.L., Hart, I.M., Kao, F.T., Neve, R.L., Bruns, G.A., Kurnit, D.M., and Patterson, D. (1987).Cytogenet. Cell Genet. 44142–147.Google Scholar
  44. 44.
    Glaser, T., Lewis, W.H., Bruns, G.A., Watkins, P.C., Rogler, C.E., Shows, T.B., Powers, V.E., Willard, H.F., Goguen, J.M., Simola, K.O., and Housman, D.E. (1986).Nature 321882–887.Google Scholar
  45. 45.
    Jones, S., and Moore, E.E. (1984).Hum. Genet. 66206–211.Google Scholar
  46. 46.
    Law, M.L., Tung, L., Morse, H.G., Berger, R., Jones, C., Cheah, K.S.E., and Solomon, E. (1986).Ann. Hum. Genet. 50131–137.Google Scholar
  47. 47.
    Besmer, P., Murphy, J.E., George, P.C., Qiu, F., Bergold, P.J., Lederman, L., Snyder, H.W., Jr., Brodeur, D., Zuckerman, E.E., and Hardy, W.D. (1986).Nature 320415–421.Google Scholar
  48. 48.
    Sherr, C.J. (1988).Leukemia 2132S-142S.Google Scholar
  49. 49.
    Murphy, E.D. (1971).Proc. Am. Assoc. Cancer Res. 1245.Google Scholar
  50. 50.
    Murphy, E.D. (1977).J. Natl. Cancer Inst. 59107–110.Google Scholar
  51. 51.
    Wang, C., Curtis, J.E., Geissler, E.N., McCulloch, E.A., and Minden, M.D. (1989).Leukemia 3699–702.Google Scholar
  52. 52.
    Crescenzi, M., Napolitano, M., Carbonari, M., Antonelli, A., Petrinelli, P., Gaetano, C., and Fiorilli, M. (1988).Blood 719–12.Google Scholar
  53. 53.
    Einhorn, S., Burvall, K., Juliusson, G., Gahrton, G., and Meeker, T. (1989).Leukemia 3871–874.Google Scholar
  54. 54.
    Nacheva, E., Fischer, P., Karpas, A., Sherrington, P., Hayhoe, F.G., Manolov, G., Manolova, Y., Ferstl, G., Haas, D., and Gadner, H. (1987).Cancer Genet. Cytogenet. 28145–153.Google Scholar
  55. 55.
    Carroll, A.J., Raimondi, S.C., Williams, D.L., Behm, F.G., Borowitz, M., Castleberry, R.P., Harris, M.B., Patterson, R.B., Pullen, D.J., and Crist, W.M. (1987).Blood 701962–1965.Google Scholar
  56. 56.
    Price, C., Haggar, D., Kanfer, E., Spoudeas, H., Samson, D., and Haworth, C. (1989).Cancer Genet. Cytogenet. 37293–295.Google Scholar
  57. 57.
    Kosmo, M.A., Mitsuyasu, R.T., Sparkes, R.S., and Gale, R.P. (1987).Cancer Genet. Cytogenet. 29245–251.Google Scholar
  58. 58.
    Hasegawa, Y., Sakai, N., Toyama, M., Ninomiya, H., and Abe, T. (1990).Rinsho Ketsueki 3175–79.Google Scholar
  59. 59.
    Larripa, I., Mecucci, C., Testoni, N., Bosly, A., Boyen, C., Tytgat, H., and Van den Berghe, H. (1987).Cancer Genet. Cytogenet. 28113–118.Google Scholar
  60. 60.
    Roberts, W.M., Douglass, E.C., Peiper, S.C., Houghton, P.J., and Look, A.T. (1989).Cancer Res. 495407–5413.Google Scholar
  61. 61.
    Haddad, P.S., Sorini, P.M., Somsin, A.A., Nathan, H.H., Dobbs, R.M., Berger, C.S., and Sandberg, A.A. (1988).J. Urol. 139748–750.Google Scholar
  62. 62.
    Geurtz van Kessel, A., van Brunen, E., de Jong, B. Oosterhuis, J.W., Langeveld, A., and Mulder, M.P. (1989).Cancer Genet. Cytogenet. 40129–134.Google Scholar
  63. 63.
    Sait, S.N., Dal Cin, P., Ovanessoff, S., and Sandberg, A.A. (1989).Cancer Genet. Cytogenet. 37157–161.Google Scholar
  64. 64.
    Vanni, R., and Lecca, U. (1988).Cancer Genet. Cytogenet. 3233–34.Google Scholar
  65. 65.
    Vanni, R., Nieddu, M., Paoli, R., and Lecca, U. (1989).Cancer Genet. Cytogenet. 3749–54.Google Scholar
  66. 66.
    Heim, S., Nilbert, M., Vanni, R., Floderus, U.M., Mandahl, N., Liedgren, S., Lecca, U., and Mitelman, P. (1988).Cancer Genet. Cytogenet. 3213–17.Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Edwin N. Geissler
    • 1
  • Martha Liao
    • 2
  • J. David Brook
    • 3
  • Francis H. Martin
    • 4
  • Krisztina M. Zsebo
    • 4
  • David E. Housman
    • 3
  • Stephen J. Galli
    • 1
  1. 1.Departments of PathologyBeth Israel Hospital and Harvard Medical SchoolBoston
  2. 2.Eleanor Roosevelt Institute for Cancer Research and Department of PediatricsUniversity of Colorado, Health Sciences CenterDenver
  3. 3.Department of Biology and Center for Cancer ResearchMassachusetts Institute of TechnologyCambridge
  4. 4.AMGEN Inc., AMGEN CenterThousand Oaks

Personalised recommendations