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Somatic Cell and Molecular Genetics

, Volume 17, Issue 2, pp 207–214 | Cite as

Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter

  • Edwin N. Geissler
  • Martha Liao
  • J. David Brook
  • Francis H. Martin
  • Krisztina M. Zsebo
  • David E. Housman
  • Stephen J. Galli
Brief Communication

Abstract

Recently a novel hematopoietic growth factor, stem cell factor (SCF), was cloned and demonstrated to be the ligand for the c-kit tyrosine kinase receptor. In the mouse, SCF is encoded bySl (steel), a gene critical to the development of several distinct cell lineages during embryonic life and which has important effects on hematopoiesis in the adult animal. TheS1/SCF locus maps to the distal region of mouse chromosome 10, in the vicinity of genes that have been mapped to human chromosome 12. Here we report the use of somatic cell hybrid lines to localizeSCF to the long arm of human chromosome 12, between 12q14.3 and 12qter. In addition to localizing theSl homolog in man, these data provide further evidence for the conservation of synteny between the long arm of human chromosome 12 and the distal end of mouse chromosome 10.

Keywords

Tyrosine Somatic Cell Tyrosine Kinase Receptor Human Chromosome Adult Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Edwin N. Geissler
    • 1
  • Martha Liao
    • 2
  • J. David Brook
    • 3
  • Francis H. Martin
    • 4
  • Krisztina M. Zsebo
    • 4
  • David E. Housman
    • 3
  • Stephen J. Galli
    • 1
  1. 1.Departments of PathologyBeth Israel Hospital and Harvard Medical SchoolBoston
  2. 2.Eleanor Roosevelt Institute for Cancer Research and Department of PediatricsUniversity of Colorado, Health Sciences CenterDenver
  3. 3.Department of Biology and Center for Cancer ResearchMassachusetts Institute of TechnologyCambridge
  4. 4.AMGEN Inc., AMGEN CenterThousand Oaks

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