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Diabetologia

, Volume 17, Issue 2, pp 97–99 | Cite as

Absorption kinetics of subcutaneously injected insulin

Evidence for degradation at the injection site
  • M. Berger
  • P. A. Halban
  • L. Girardier
  • J. Seydoux
  • R. E. Offord
  • A. E. Renold
Originals

Summary

The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.

Key words

Tritiated insulin subcutaneous insulin injections chemical analysis of injection site absorption kinetics local insulin degradation 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • M. Berger
    • 1
    • 4
  • P. A. Halban
    • 1
  • L. Girardier
    • 2
  • J. Seydoux
    • 2
  • R. E. Offord
    • 3
  • A. E. Renold
    • 1
  1. 1.Institut de Biochimie CliniqueUniversity of GenevaSwitzerland
  2. 2.Department of PhysiologyUniversity of GenevaSwitzerland
  3. 3.Laboratory of Molecular Biophysics, Department of ZoologyUniversity of OxfordEngland
  4. 4.II. Medizinische UniversitätsklinikDüsseldorfFederal Republic of Germany

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