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Diabetologia

, Volume 10, Supplement 1, pp 617–623 | Cite as

Further characterization of diabetes-like abnormalities in the T-KK mouse

  • B. M. Wyse
  • W. E. Dulin
Article

Summary

The sequence of development and regression of several abnormalities of T-KK mice was studied in comparison with C57BL/6 mice. Food intake, body weights, blood sugars and plasma insulins were determined at approximately monthly intervals from 2–16 months. Insulin sensitivity, glucose tolerance andin vivo gluconeogenesis were studied at about 2 months, 5–6 months and at one year. Plasma growth hormone and glucose oxidation by isolated islets were also studied and determination of life span was made. — It was not possible to determine which abnormality occurred first in the T-KK mouse, since at 2 months significant changes in all parameters were already present. The reversal of plasma insulin and blood glucose occurred before the decreased food intake and body weights. These results were interpreted to mean that the changes in insulin and glucose may be under genetic control. — Insulin sensitivity and tolerance to glucose decreased andin vivo gluconeogenesis increased when the T-KK mice were obese, hyperglycemic and hyperinsulinemic. These changes reverted to normal after the animals lost weight and blood sugars and plasma insulin had returned to normal. Survival dropped in T-KK mice and these earlier deaths appeared to coincide with normalization of body weight, blood sugar and plasma insulin. These observations indicated that the abnormalities in the T-KK mouse are of importance to survival. — Plasma growth hormone was decreased in the fasted T-KK mice and there was no difference from normal when animals were fed. Therefore, an increase in growth hormone does not play a role in the pathogenesis of abnormalities in the T-KK mouse. Oxidation of glucose-1-14 C and -6-14C in isolated islets from T-KK mice was increased therefore confirming the hyperactivity of the islets.

Key words

Diabetes T-KK mice hyperglycemia normalization hyperinsulinemia growth hormone islets 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • B. M. Wyse
    • 1
  • W. E. Dulin
    • 1
  1. 1.Diabetes and Atherosclerosis ResearchThe Upjohn CompanyKalamazooUSA

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