Diabetologia

, Volume 10, Supplement 1, pp 589–593 | Cite as

Aortic glucose metabolism in the diabetic Chinese hamster

  • Aram V. Chobanian
  • George C. Gerritsen
  • Peter I. Brecher
  • Louis McCombs
Article

Summary

The influence of diabetes and insulin therapy on arterial glucose metabolism was studied in the Chinese hamster. Total glucose utilization and conversion of glucose to lactic acid, CO2, lipid, glycogen, and protein were significantly reduced in intima-media segments of diabetic hamster aorta incubatedin vitro. The degree of reduction was greater in the ketotic than the non-ketotic diabetics. The abnormalities in glucose metabolism did not appear to be related to a defect in glucose transport. Administration of insulinin vivo for up to 72 h in doses sufficient to normalize plasma glucose and insulin did not influence aortic glucose utilization. However, treatment with large doses of insulin, which produced marked hyperinsulinemia and mild hypoglycemia, corrected the observed reductions in glucose incorporation. Addition of insulinin vitro had no significant effect on aortic glucose metabolism.

Key words

Arterial metabolism diabetes mellitus arterial metabolism insulin Chinese hamster 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Aram V. Chobanian
  • George C. Gerritsen
    • 1
    • 2
  • Peter I. Brecher
    • 1
    • 2
  • Louis McCombs
    • 1
    • 2
  1. 1.Cardiovascular InstituteBoston University Medical CenterBoston
  2. 2.Diabetes and Atherosclerosis ResearchThe Upjohn CompanyKalamazooUSA

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