Effect of diet limitation on the development of diabetes in prediabetic Chinese hamsters
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Prediabetic Chinese hamsters born of two ketonuric diabetic parents were hyperphagic from birth. Carcass lipids and total solids were increased but plasma and pancreatic insulin were not, suggesting that hyperphagia was not due to hyperinsulinism. Hyperphagia was controlled by diet limitation of prediabetic pups. Diet limitation for the weaning period only did not alter development of diabetes, but diet limitation for the first 150 days significantly reduced onset and severity. These 150 day diet-limited prediabetics were switched to nonrestricted feeding and subsequently developed mild diabetes. Prediabetic siblings, fedad libitum, developed glucosuria and ketonuria, and died prematurely compared with diet-limited siblings. Prediabetics limited to a normal food intake for 30 months have remained essentially clinically normal. The data strongly suggest that appetite control mechanisms are abnormal prior to clinical signs of diabetes in the prediabetic Chinese hamster and that control of hyperphagia will retard anameliorate the course of diabetes.
Key wordsChinese hamster prediabetes diabetes diet-limitation diabetes prevention diabetes ameliorati on, and increased longevity.
- 2.Gerritsen, G.C., Chang, A.Y., Schneider, D.I., Needham, L.B., Blanks, M.C.: Studies on prediabetic Chinese hamsters. Diabetes.20, 356 (1971)Google Scholar
- 3.Gerritsen, G.C., Dulin, W.E.: Effect of diet restriction on onset of development of diabetes in prediabetic Chinese hamsters. Acta diabet. lat.9 (Suppl.), 597–613 (1972)Google Scholar
- 4.Bouchardat, H.: De La Glucosurie du Diabète Sucré. Paris 1883Google Scholar
- 5.Pyke, D.A.: In: Clinical diabetes and its biochemical basis (Oakley, W.G., Pyke, D.A., Taylor, K.W., eds.) p. 245. London: Blackwell 1968Google Scholar
- 7.Dulin, W.E., Gerritsen, G.C.: Interaction of genetics and environment on diabetes in the Chinese hamster as compared with human and other diabetic animal species. Acta diabet. lat.9 (Suppl. 1), 48–84 (1972)Google Scholar
- 9.Blanks, M.C., Gerritsen, G.C.: An ultramicro assay for insulin. Proc. Soc. exp. Biol. (N.Y.)146, 448–452 (1974)Google Scholar
- 12.Natelson, S.: Microtechniques of clinical chemistry, p. 101. Springfield, Ill.: C.C. Thomas 1961Google Scholar
- 13.Snell, C.T., Snell, F.D.: Colorimetric methods of analysis, p. 184. Toronto: D. van Nostrand 1945Google Scholar
- 16.May, K.K., Beaton, J.R.: Hyperphagia in the insulin-treated rat. Proc. Soc. exp. Biol. (N.Y.)127, 1201–1204 (1968)Google Scholar
- 17.Oakley, N.W., Beard, R.W., Turner, R.C.: Effect of sustained maternal hyperglycaemia on the fetus in normal and diabetic pregnancies. Brit. med. J. 1972I, 466–469Google Scholar
- 25.Allison, R.S.: Carbohydrate tolerance in overweight and obesity. Lancet 1927I, 537–540Google Scholar
- 26.Joslin, E.P., Dublin, L.T., Marks, H.H.: Studies in diabetes mellitus. IV. Etiology. Amer. J. med. Sci.192, 9–23 (1936)Google Scholar