, Volume 15, Issue 1, pp 29–32

Thyroid hormones in insulin requiring diabetes before and after treatment

  • J. Saunders
  • S. E. H. Hall
  • P. H. Sönksen


Thyroid hormones have been measured in normal subjects and insulin-requiring diabetic patients before and after treatment. Plasma thyroxine (T4) and 3, 3′, 5-triiodothyronine (T3) concentrations were both low in diabetics, with T3 frequently in the hypothyroid range, while 3, 3′, 5′-triiodothyronine (rT3) concentrations were elevated. All three returned to normal following treatment. T3 concentration was directly related to glucose utilization and metabolic clearance rate; and inversely related to plasma ketone body concentration. Thyroid hormone abnormalities in diabetes may reflect the degree of insulin-secreting capacity.

Key words

Thyroxine triiodothyronine reverse T3 glucose utilization glucose metabolic clearance rate ketones oxygen consumption cortisol insulin 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • J. Saunders
    • 1
  • S. E. H. Hall
    • 1
  • P. H. Sönksen
    • 1
  1. 1.Department of MedicineSt. Thomas's Hospital Medical SchoolLondonEngland

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