Journal of Neurocytology

, Volume 19, Issue 2, pp 200–212 | Cite as

Cajal-Retzius neurons in developing monkey neocortex show immunoreactivity for calcium binding proteins

  • G. W. Huntley
  • E. G. Jones


Immunoreactivity for two calcium binding proteins, 28 kDa calbindin and parvalbumin, was used to label cells morphologically identical to Cajal-Retzius neurons in the developing visual, prefrontal, sensory-motor and temporal cortex of Old World monkeys. At all fetal ages examined (E110–E155), Cajal-Retzius neurons throughout the cortex were immunoreactive for calbindin as well as being acetylcholinesterase positive. Between E130 and E150, the calbindin-immunoreactive Cajal-Retzius cells in the visual cortex, and a few in other cortical areas, also showed parvalbumin immunoreactivity. A reduced population of immunoreactive Cajal-Retzius cells was detected at birth, and none could be visualized by immunocytochemistry or histochemistry at later postnatal ages. Calbindin and parvalbumin immunoreactivity represents a potentially useful marker for this developmentally regulated population of neurons, and the varied expression of the two proteins suggests that Cajal-Retzius neurons may represent a neurochemically heterogeneous cell population.


Calcium Cell Population Visual Cortex Cortical Area Acetylcholinesterase 
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Copyright information

© Chapman and Hall Ltd 1990

Authors and Affiliations

  • G. W. Huntley
    • 1
  • E. G. Jones
    • 1
  1. 1.Department of Anatomy and NeurobiologyUniversity of CaliforniaIrvineUSA

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