Human Genetics

, Volume 87, Issue 1, pp 81–83 | Cite as

Chromosome abnormalities found among 34910 newborn children: results from a 13-year incidence study in Århus, Denmark

  • Johannes Nielsen
  • Mogens Wohlert
Short Communications

Summary

As part of a larger prospective study of the influence of environmental factors on pregnancy, birth and the fetus, chromosome examinations have been made in 34910 newborn children in Århus over a 13-year period. Klinefelter's syndrome was found in 1 per 576 boys, XYY in 1 per 851 boys, triple-X in 1 per 947 girls and Turner's syndrome in 1 per 1893 girls. Other sex chromosome aberrations were found in 1 per 11637 children. The total incidence of sex chromosome abnormalities was 1 per 426 children or 2.34 per 1000. The most frequent autosomal abnormalities were that of Down's syndrome with 1 per 592 children, and reciprocal translocations with 1 per 712 children. The total incidence of autosomal abnormalities was 1 per 164 children. Chromosome abnormalities were found in 276 liveborn children and in 19 fetuses, who were aborted after prenatal chromosome examination. The combined incidence of sex chromosomal and autosomal abnormalities was 1 per 118 children or 8.45 per 1000 children.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gravholt C, Friedrich U, Nielsen J (1991) Chromosomal mosaicism — a follow-up study of 39 unselected children found at birth. Hum Genet (in press)Google Scholar
  2. Nielsen J (1976) Cell selection in vivo in normal/aneuploid chromosome abnormalities. Hum Genet 32:203–206PubMedGoogle Scholar
  3. Nielsen J (1990) Follow-up of 25 unselected children with sex chromosome abnormalities till the age of 10–14 years. Birth Defects 76:201–207Google Scholar
  4. Nielsen J, Krag-Olsen B (1980) Cell selection in vivo. Follow-up of nine unselected mixoploid children. Hum Genet 55:357–361PubMedGoogle Scholar
  5. Nielsen J, Krag-Olsen B (1981) Follow-up of 32 children with autosomal translocations found among 11148 consecutively new-born children from 1969 to 1974. Clin Genet 20:48–54PubMedGoogle Scholar
  6. Nielsen J, Sillesen I (1975) Incidence of chromosome aberrations among 11148 newborn children. Hum Genet 30:1–12Google Scholar
  7. Nielsen J, Wohlert M (1990) Sex chromosome abnormalities found among 34910 newborn children: results from a 13-year incidence study in Århus, Denmark. Birth Defects 26:209–223PubMedGoogle Scholar
  8. Nielsen J, Sillesen I, Sørensen AM, Sørensen K (1979) Follow-up until age 4 to 8 of 25 unselected children with sex chromosome abnormalities, compared with sibs and controls. Birth Defects 15:15–73PubMedGoogle Scholar
  9. Nielsen J, Wohlert M, Faaborg-Andersen J, Hansen KB, Hvidman L, Krag-Olsen B, Moulvad I, Videbech P (1982a) Incidence of chromosome abnormalities in newborn children. Comparison between incidences in 1969–1974 and 1980–1982 in the same area. Hum Genet 61:98–101PubMedGoogle Scholar
  10. Nielsen J, Sørensen AM, Sørensen K (1982b) Follow-up until age 7 to 11 of 25 unselected children with sex chromosome abnormalities. Birth Defects 18:61–97Google Scholar
  11. Nielsen J, Wohlert M, Faaborg-Andersen J, Eriksen G, Hansen KB, Hvidman L, Krag-Olsen B, Moulvad I, Videbech PN (1986) Chromosome examination of 20222 newborn children: results from a 7.5-year study in Århus, Denmark. Birth Defects 22:209–219PubMedGoogle Scholar
  12. Ratcliffe SG, Paul N (1986) Prospective studies on children with sex chromosome aneuploidy. Birth Defects 22:1–327Google Scholar
  13. Robinson A, Lubs HA, Bergsma D (1979) Sex chromosome aneuploidy: prospective studies on children. Birth Defects 15:1–281Google Scholar
  14. Stewart DA (1982) Children with sex chromosome aneuploidy: follow-up studies. Birth Defects 18:1–251Google Scholar
  15. Wohlert M (1989) Biologiske, sociale og organisatoriske forholds betydning for komplikationer i forbindelse med graviditet og fødsel. FaDL, AarhusGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Johannes Nielsen
    • 1
  • Mogens Wohlert
    • 2
  1. 1.Cytogenetic Laboratory, Århus Psychiatric HospitalRisskovDenmark
  2. 2.Gynecological-Obstetric Department YÅrhus Municipal HospitalÅrhus C.Denmark

Personalised recommendations