Journal of Gastroenterology

, Volume 30, Issue 1, pp 21–27 | Cite as

Elevation of ratio of urinary N-acetylneuraminlactose to free sialic acid in some advanced cancer patients

  • Ichiroh Shimada
  • Miki Shoji
  • Ryusuke Futatsuya
  • Terutaka Katoh
  • Yoshihiko Kominato
  • Takashi Sakamoto
  • Takashi Fujikura
Alimentary Tract


We estimated the levels of free sialic acid and sialylated oligosaccharides excreted in the urine of normal donors (n=10) and patients with gastric cancer (n=6) and colorectal cancer (n=4). The total sialic acid level in cancer patients was similar to that in normal donors. However, the ratios of glycosidically bound sialic acids to free sialic acid were higher in some advanced cancer patients than in the normal donors. A major component of sialylated oligosaccharides was N-acetylneuraminyl α (2 → 3) lactose. The elevation of the urinary ratio of this sialylated oligosaccharide to free sialic acid observed in some advanced cancer patients in this study may reflect the elevation of sialyltransferase activity in tumor tissues.

Key words

gastrointestinal cancer sialic acid sialylated oligosaccharide urine 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Ichiroh Shimada
    • 1
  • Miki Shoji
    • 2
  • Ryusuke Futatsuya
    • 2
  • Terutaka Katoh
    • 3
  • Yoshihiko Kominato
    • 4
  • Takashi Sakamoto
    • 1
  • Takashi Fujikura
    • 5
  1. 1.Second Department of SurgeryToyama Medical and Pharmaceutical UniversityToyamaJapan
  2. 2.Department of Radiological SciencesToyama Medical and Pharmaceutical UniversityToyamaJapan
  3. 3.Department of Public HealthToyama Medical and Pharmaceutical UniversityToyamaJapan
  4. 4.Department of Legal Medicine, Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyamaJapan
  5. 5.Department of Legal Medicine, Faculty of MedicineFujita Health University School of MedicineToyoakeJapan

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