Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons
The neurogenetic process leading to the formation of primary sensory neurons persists into adult life in the olfactory epithelium of mammals. The morphological stages of maturation and ageing of this exceptional neuron have been described both at light and electron microscopical levels. For descriptive purposes the neural elements have been classified as: (1) basal cells proper, (2) globose basal cells, and (3) neurons. Intermediate stages, however, have been identified. Autoradiographic observations complement the morphological studies and provide a time sequence of the morphological stages leading to the mature neurons.
A typical columnar arrangement of the sensory neurons has been described. Furthermore, active and quiescent zones have been recognized in the neuroepithelium. In the active zones the neurogenetic process is vigorous, and the zones are characterized by the presence of immature elements. However, in the quiescent zones there exists a population of mature elements while immature neurons are sparse.
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- Altman, J. (1970) InDevelopmental Neurobiology. (edited byHimwich, W. A.) pp. 197–237. Springfield: Thomas.Google Scholar
- Bullock, T. H. andHorridge, G. A. (1965)Structure and Function in the Nervous System of Invertebrates. Vol. 1. San Francisco, London: Freeman.Google Scholar
- Cajal, S. R. Y. (1911)Histologie du Système Nerveux de l'homme et des vertébrés. Vol. II. Paris: Maloine.Google Scholar
- Graziadei, P. P. C. (1965) Sensory receptor cells and related neurons in cephalopods.Cold Spring Harbor Symposium on Quantitative Biology 30, 45–57.Google Scholar
- Graziadei, P. P. C. (1971) The olfactory mucosa of vertebrates. InHandbook of Sensory Physiology, (edited byBeidler, M.) Vol. IV. pp. 27–58. New York, Heidelberg, Berlin: Springer Verlag.Google Scholar
- Graziadei, P. P. C. (1976) Functional anatomy of the mammalian chemoreceptor system. InChemical signals in vertebrates, (edited byMueller Schwarze, D. andMozell, M. M.) pp. 435–54. New York: Plenum Press.Google Scholar
- Graziadei, P. P. C. andMetcalf, J. F. (1971) Autoradiographic studies of frog's olfactory mucosa.Zeitschrift für Zellforschung 116, 305–18.Google Scholar
- Graziadei, P. P. C. andMonti Graziadei, G. A. (1978a) Continuous nerve cell renewal in the olfactory system, InHandbook of Sensory Physiology. Vol. IX, pp. 55–82. (edited byJacobson, M.) New York, Berlin, Heidelberg: Springer Verlag.Google Scholar
- Graziadei, P. P. C. andMonti Graziadei, G. A. (1978b) The olfactory system: a model for the study of neurogenesis and axon regeneration in mammals. InNeuronal Plasticity. (edited byCotman, C. W.) pp. 131–53. New York: Raven Press.Google Scholar
- Hinds, J. W. andMcNelly, U. A. (1977) Ageing of the rat olfactory bulb: growth and atrophy of constituent layers and changes in size and number of mitral cells.Journal of Comparative Neurology 171, 345–68.Google Scholar
- Moulton, D. G., Celebi, G. andFink, R. P. (1970) Olfaction in mammals: proliferation of cells in the olfactory epithelium and sensitivity to odours. InTaste and Smell in Vertebrates. CIBA Foundation Symposium. (edited byWolstenholme, G. E. W. andKnight, J.) pp. 227–246. London: Churchill.Google Scholar
- Oley, N., DeHan, R. S., Tucker, D., Smith, J. C. andGraziadei, P. P. C. (1975) Recovery of function and structure following transection of the primary olfactory nerves in pigeon.Journal of Comparative Physiology and Psychology 88, 477–95.Google Scholar
- Rogers, A. W. (1967)Techniques of Autoradiography. p. 335. New York: Elsevier.Google Scholar
- White, E. L. (1972) Synaptic organization of the olfactory glomerulus of mouse.Brain Research 37, 69–80.Google Scholar