Journal of Assisted Reproduction and Genetics

, Volume 9, Issue 4, pp 338–344 | Cite as

Improved pregnancy outcome with gonadotropin releasing hormone agonist (GnRH-a) stimulation is due to the improvement in oocyte quantity rather than quality

  • Hung-Ching Liu
  • Ying-Ming Lai
  • Owen Davis
  • Alan S. Berkeley
  • Margaret Graf
  • Jimmy Grifo
  • Jacques Cohen
  • Zev Rosenwaks
Clinical Assisted Reproduction


The impact of gonadotropin releasing hormone agonist (GnRH-a) on the quality and quantity of oocytes harvested in in vitro fertilization—embryo transfer (IVF-ET) patients was studied by comparing the results for patients stimulated with gonadotropin alone and with gonadotropin plus GnRH-a. Adding GnRH-a significantly improved the viable pregnancies per transfer and reduced the spontaneous abortions, which seemed to improve oocyte quality. However, when oocyte quality was evaluated by the fertilization rate and the implantation and delivery rates per embryos transferred, there were no significant difference in the results, indicating that GnRH-a did not improve the oocyte quality. On the other hand, GnRH-a significantly increased the average number of oocytes harvested, fertilized, and transferred, and this increased number of oocytes transferred has been demonstrated to increase pregnancy and multiple-pregnancy rates. Multiple pregnancy with more embryos implanted would significantly reduce the abortion rate. Abortion rates decreased inversely to the number of embryos implanted. Our data strongly suggest that the efficacy of GnRH-a on IVF-ET patients was due more to the quantity increase than the quality of embryos transferred.

Key words

embryo quality embryo quantity gonadotropin releasing hormone agonist implantation rate multiple pregnancy 


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Hung-Ching Liu
    • 1
  • Ying-Ming Lai
    • 2
  • Owen Davis
    • 1
  • Alan S. Berkeley
    • 1
  • Margaret Graf
    • 1
  • Jimmy Grifo
    • 1
  • Jacques Cohen
    • 1
  • Zev Rosenwaks
    • 1
  1. 1.Center for Reproductive Medicine and Infertility, Department of Obstetrics and GynecologyCornell University Medical CollegeNew YorkUSA
  2. 2.Department of Obstetrics and GynecologyChang Gung Memorial HospitalTaipeiR.O.C.

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