Documenta Ophthalmologica

, Volume 87, Issue 4, pp 337–354 | Cite as

Slowly progressive changes of the retina and retinal pigment epithelium in briard dogs with hereditary retinal dystrophy

A morphological study
  • Anders Wrigstad
  • Kristina Narfström
  • Sven Erik G. Nilsson
Article

Abstract

Seven eyes from 2 generations of Briard dogs (5 weeks — 7 years old) with congenital night blindness and (in the second generation) impairment of day vision to varying degrees, were examined by light and electron microscopy. Specimens from 4 locations were studied: the central area, the midperiphery of the tapetal area, the upper periphery and the lower periphery. Disorientation of rod outer segment disc membranes was seen in the 5-week-old dog. Large electron-lucent inclusions were found in the RPE at 3.5 months of age. These inclusions occurred most frequently in the central and midperipheral-tapetal areas and seemed to increase in numbers and spread towards the periphery with increasing age. The content of these inclusions is not elucidated. Rod photoreceptor degeneration was apparent from 7 months of age and was most prominent in the peripheral areas. The cones were better preserved. The 7-year-old dog showed reduction of photoreceptors in the central and midperipheral-tapetal areas and almost complete photoreceptor degeneration in the periphery. This dog also showed severe changes of the inner retina in the peripheral fundus. It appears that these Briard dogs suffer from a very slowly progressive retinal degeneration, in which the photoreceptor degenerative changes do not correlate anatomically to the changes in the RPE cells. The disease seems to be different from the retinopathy described in the English Briards. It is not clear yet whether the lipid type of retinopathy found in American Briards is identical to the present disease.

Key words

Animal model Briard dogs Electron microscopy Photoreceptors Retinal degeneration Retinal pigment epithelium 

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References

  1. 1.
    Aguirre G. Inherited retinal degenerations in the dog. Trans Am Acad Ophthalmol Otol 1976; 81: 667–76.Google Scholar
  2. 2.
    Aguirre G, Farber D, Lolley R, Fletcher RT, Chader GJ. Rod-cone dysplasia in Irish Setters: a defect in cyclic GMP metabolism in visual cells. Science 1978; 201: 1133–4.PubMedGoogle Scholar
  3. 3.
    Aguirre G, Farber D, Lolley R, O'Brien P, Alligood J, Fletcher RT et al. Retinal Degenerations in the Dog III: Abnormal Cyclic Nucleotide Metabolism in Rod-Cone Dysplasia. Exp Eye Res 1982; 35: 625–42.PubMedGoogle Scholar
  4. 4.
    Aguirre GD, Acland GM, Chader G. Hereditary Retinal Degenerations in the Dog: Specificity of Abnormal Cyclic Nucleotide Metabolism to Diseases of Arrested Photoreceptor Development. Birth Defects 1982; 18: 119–33.PubMedGoogle Scholar
  5. 5.
    Buyukmihci N, Aguirre G, Marshall J. Retinal Degenerations in the Dog II. Development of the Retina in Rod-Cone Dysplasia. Exp Eye Res 1980; 30: 575–91.PubMedGoogle Scholar
  6. 6.
    Wolf ED, Vainisi SJ, Santos-Anderson R. Rod-Cone Dysplasia in the Collie. J Am Vet Med Assoc 1978; 173: 1331–3.PubMedGoogle Scholar
  7. 7.
    Santos-Anderson RM, Tso MOM, Wolf ED. An inherited retinopathy in collies. A light and electron microscopic study. Invest Ophthalmol Vis Sci 1980; 19: 1281–94.PubMedGoogle Scholar
  8. 8.
    Woodford BJ, Liu Y, Fletcher RT, Chader GJ, Farber DB, Santos-Anderson R et al. Cyclic Nucleotide Metabolism in Inherited Retinopathy in Collies: A Biochemical and Histochemical Study. Exp Eye Res 1982; 34: 703–14.PubMedGoogle Scholar
  9. 9.
    Aguirre G. Retinal Degenerations in the Dog. I. Rod Dysplasia. Exp Eye Res 1978; 26: 233–53.PubMedGoogle Scholar
  10. 10.
    Acland GM, Aguirre GD. Retinal degenerations in the Dog: IV. Early Retinal Degeneration (erd) in Norwegian Elkhounds. Exp Eye Res 1987; 44: 491–521.PubMedGoogle Scholar
  11. 11.
    Parshall CJ, Wyman M, Nitroy S, Acland G, Aguirre G. Photoreceptor Dysplasia: An Inherited Progressive Retinal Atrophy of Miniature Schnauzer Dogs. Prog Vet Comp Ophthalmol 1991; 1: 187–203.Google Scholar
  12. 12.
    Aguirre G, Alligood J, O'Brien P, Buyukmihci N. Pathogenesis of progressive rod-cone degeneration in miniature poodles. Invest Ophthalmol Vis Sci 1982; 23: 610–30.PubMedGoogle Scholar
  13. 13.
    Aguirre GD, Acland GM. Variation in Retinal Degeneration Phenotype Inherited at the prcd Locus. Exp Eye Res 1988; 46: 663–87.PubMedGoogle Scholar
  14. 14.
    Aguirre G, Acland G. Inherited retinal degeneration in the Labrador retriever dog. A new animal model of RP? Invest Ophthalmol Vis Sci 1991; 32 (ARVO suppl):889.Google Scholar
  15. 15.
    Parry HB. Degenerations of the Dog Retina. VI. Central Progressive Atrophy with Pigment Epithelial Dystrophy. Br J Ophthalmol 1954; 38: 653–68.PubMedGoogle Scholar
  16. 16.
    Aguirre GD, Laties A. Pigment Epithelial Dystrophy in the Dog. Exp Eye Res 1976; 23: 247–56.PubMedGoogle Scholar
  17. 17.
    Barnett KC, Curtis R. Retinal Degenerations in the Dog and Cat as Models for Retinitis Pigmentosa. Trans Ophthalmol Soc UK 1983; 103: 448–52.PubMedGoogle Scholar
  18. 18.
    Rubin LF. Briard. In: Inherited Eye Diseases in Purebred Dogs. Baltimore: Williams & Wilkins 1989; 56–8.Google Scholar
  19. 19.
    Bedford PCG. Retinal pigment epithelial dystrophy (CPRA): A study of the disease in the Briard. J Small Anim Pract 1984; 25: 129–38.Google Scholar
  20. 20.
    Riis RC, Aguirre GD. The Briard Problem. Proc Am Coll Vet Ophth 1983; 62–75.Google Scholar
  21. 21.
    Narfström K, Wrigstad A, Nilsson SEG. The Briard dog: a new animal model of congenital stationary night blindness. Br J Ophthalmol 1989; 73: 750–6.PubMedGoogle Scholar
  22. 22.
    Narfström K, Wrigstad A, Ekesten B, Nilsson SEG. Hereditary Retinal Dystrophy in the Briard Dog: Clinical and Hereditary Characteristics. Prog Vet Comp Ophthalmol 1994; 4: 85–92.Google Scholar
  23. 23.
    Nilsson SEG, Wrigstad A, Narfström K. Changes in the DC Electroretinogram in Briard Dogs with Hereditary Congenital Night Blindness and Partial Day Blindness. Exp Eye Res 1992; 54: 291–6.PubMedGoogle Scholar
  24. 24.
    Wrigstad A, Nilsson SEG, Narfström K. Ultrastructural Changes of the Retina and the Retinal Pigment Epithelium in Briard Dogs with Hereditary Congenital Night Blindness and Partial Day Blindness. Exp Eye Res 1992; 55: 805–18.PubMedGoogle Scholar
  25. 25.
    Riis RC, Siakotos AB. Inherited lipid retinopathy within a dog breed. Invest Ophthalmol Vis Sci 1989; 31 (ARVO suppl): 308.Google Scholar
  26. 26.
    Williams MA, Pinto LH, Gherson J. The Retinal Pigment Epithelium of Wild Type (C57BL/6J +/+) and Pearl Mutant (C57BL/ 6J pe/pe) Mice. Invest Ophthalmol Vis Sci 1985; 26: 657–69.PubMedGoogle Scholar
  27. 27.
    Williams MA, Gherson J, Fisher LJ, Pinto LH. Synaptic Lamellae of the photoreceptors of Pearl and Wild-type Mice. Invest Ophthalmol Vis Sci 1985; 26: 992–1001.PubMedGoogle Scholar
  28. 28.
    Mizuno K, Nishida S. Electron Microscopic Studies of Human Retinitis Pigmentosa. Two Cases of Advanced Retinitis Pigmentosa. Am J Ophthalmol 1967; 63: 791–803.PubMedGoogle Scholar
  29. 29.
    Berson EL, Adamian M. Ultrastructural Findings in an Autopsy Eye From a Patient With Usher's Syndrome Type II. Am J Ophthalmol 1992; 114: 748–57.PubMedGoogle Scholar
  30. 30.
    Barrong SD, Chaitin MH, Fliesler SJ, Possin DE, Jacobson SG, Milam AH. Ultrastructure of Connecting Cilia in Different Forms of Retinitis Pigmentosa. Arch Ophthalmol 1992; 110: 706–10.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Anders Wrigstad
    • 1
  • Kristina Narfström
    • 1
    • 2
  • Sven Erik G. Nilsson
    • 1
  1. 1.Department of OphthalmologyUniversity of LinköpingLinköpingSweden
  2. 2.Department of Surgery and MedicineFaculty of Veterinary Medicine, Swedish University of Agricultural SciencesUppsalaSweden

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