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Journal of Cancer Research and Clinical Oncology

, Volume 121, Issue 2, pp 98–102 | Cite as

6-amino-6-deoxyascorbic acid induces apoptosis in human tumor cells

  • M. Grdiša
  • M. Kralj
  • M. Eckert-Maksić
  • Z. B. Maksić
  • K. Pavelić
Original Paper Experimental Oncology

Abstract

6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.

Key words

6-amino-6-deoxyascorbic acid Apoptosis Tumor cells 

Abbreviations

NH2-ascorbate

6-amino-6-deoxyascorbic acid

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. Grdiša
    • 1
  • M. Kralj
    • 1
  • M. Eckert-Maksić
    • 1
  • Z. B. Maksić
    • 1
  • K. Pavelić
    • 1
  1. 1.Department of Molecular MedicineRuder Bošković InstituteZagrebCroatia

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