Eicosapolyynoic acids, inhibitors of lipoxygenases, weaken the short-term plasticity of cholinoreceptors of neurons of the edible snail
- 10 Downloads
The influence of three polyacetylenic analogs of natural poly enoic acids which are inhibitors of their lipoxygenase oxidation on the dynamics of the extinction of the inward current induced by repeated iontophoretic applications of acetylcholine to the soma was investigated in identified RPa3 and LPa3 of the edible snail using the method of bielectrode recording of the potential on the membrane. It was found that eicosa-5,8,ll,14-tetraynoic acid (30–60 μmole/liter) and eicosa-5,8,11,14,17-pentaynoic acid (4–50 μmole/liter) decrease the amplitude of the inward current induced by application of acetylcholine, and attenuate its extinction during repeated applications. The third analog, eicosa-8, 11,14-triaynoic acid, does not exert a modulating influence on the magnitude of the current and its extinction. It was hypothesized that the lipoxygenase metabolites of the polyenoic acids regulate the plasticity of the cholinoreceptors of the neurons of the edible snail. Taking the nonidentical inhibition by the compounds used of the various lipoxygenases into account, the participation in the plasticity of the cholinoreceptors of those eicosanoids which are formed from arachidonic acid under the influence of 5-lipoxygenases is most probable. At the same time, a regulatory role of the eicosanoids formed under the influence of other Hpoxygenases is not excluded.
Unable to display preview. Download preview PDF.
- 1.D. A. Zabolotskii, G. I. Myagkova, and R. P. Evstigneeva, “Inhibitors of lipoxygenase transformation of polyenoic acids,”Usp. Khim.,59, No. 5, 827–861 (1990).Google Scholar
- 2.A. S. Pivovarov, E. I. Drozdova, and B. I. Kotlyar, “Arachidonic acid and its acyclic derivatives regulate the short-term plasticity of the cholinoreceptors of the neurons of the edible snail,”Zh. Vyssh. Nervn. Deyat.,41, No. 4, 796–805.Google Scholar
- 3.D. G. Ahern and D. J. Bowing, “Inhibition of prostaglandin biosynthesis by eicosa-5,8,11,14-tetraynoic acid,”Biochim. Biophys. Acta,210, No. 3, 456–461 (1970).Google Scholar
- 4.E. J. Corey, “Enzymic lipoxygenation of arachidonic acid: mechanism, inhibition, and role in eicosanoid biosynthesis,”Pure a. Appl. Chem.,59, No. 3, 269–278 (1987).Google Scholar
- 5.C. R. Pace-Asciak and S. Asotra, “Biosynthesis catabolism and biological properties of HPETEs hydroperoxide derivatives and arachidonic acid,”Free Radical Biol. and M ed.,7, No. 3, 409–433 (1989).Google Scholar
- 6.D. Piomelli, E. Shapiro, S. L. Feinmark, and J. H. Schwartz, “Metabolism of arachidonic acid in the neurons system ofAplysia — possible mediators of synaptic modulation,”J. Neurosci.,7, No. 11, 3675–3686 (1987).Google Scholar
- 7.J. P. Robinson and D. A. Kendall, “No role for phospholipase A2 and protein kinase C in the potentiation by α-andrenoreceptors [sic] of β-andrenoreceptor-mediated [sic] cyclic AMP formation in the rat brain,”J. Neurochem.,51, No. 2, 542–550 (1989).Google Scholar
- 8.J. Stjernschantz, “The leukotriens,”Med. Biol,62, No. 4, 215–230 (1984).Google Scholar
- 9.F. F. Sun, J. C. McGuire, D. R. Morton, et al., “Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds,”Prostaglandins,21, No. 2, 333–343 (1981).Google Scholar