Neuroscience and Behavioral Physiology

, Volume 16, Issue 2, pp 111–118 | Cite as

Effect of substance P on behavior and cortical neuron activity during learning in rabbits

  • G. I. Shul'gina
  • I. P. Levshina
  • A. M. Melekhova
  • K. Hecht
Article
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Conclusions

  1. 1.

    In experiments on conscious, loosely restrained rabbits, using a subcutaneously administered undecapeptide, substance P, in doses of 250 μg/kg, behavior and neuron activity was studied in the visual and sensorimotor areas of the neocortex and in the hippocampus during elicitation of the defense reflex conditioned to light flashes and conditioned inhibition.

     
  2. 2.

    Introduction of sP evoked a short-term loss of motor reactions to the reinforcing stimulus; a lowering in probability of movements to reinforced and inhibitory light flashes; and a prolonged quickening of heartrate and slowing of breathing rate.

     
  3. 3.

    The background action of sP, among the majority of investigated neurons responding to stimulus presentations, resulted in a fall in background activity and a weakening of excitatory and strengthening of inhibitory response components, especially to the painful reinforcing stimulus. Some neurons showed an increase in excitatory reactions.

     
  4. 4.

    Bioelectric indicators reflecting a strengthening of inhibitory hyperpolarization processes during internal inhibition were unaffected: inhibitory background pauses and evoked activity in cerebral cortex neurons, together with corresponding slow potential fluctuations, were unchanged by sP.

     

Keywords

Neuron Activity Inhibitory Response Background Action Conditioned Inhibition Light Flash 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Literature cited

  1. 1.
    L. I. Bol'shev and I. V. Smirnov, Statistical Tables [in Russian], Nauka, Moscow (1965).Google Scholar
  2. 2.
    O. S. Vinogradova, The Hippocampus and Memory [in Russian], Nauka, Moscow (1975), p. 333.Google Scholar
  3. 3.
    I. P. Pavlov, Twenty Years' Objective Study of Higher Nervous Activity (Behavior) in Animals [in Russian], Nauka, Moscow (1973).Google Scholar
  4. 4.
    V. G. Skrebitskii, Regulation of Excitatory Activity in the Visual Analyzer [in Russian], Meditsina, Moscow (1977), p. 159.Google Scholar
  5. 5.
    G. I. Shul'gina, “Slow potentials and cortical neuron impulses during internal inhibition,” Zh. Vyssh. Nerv. Deyat.,26, No. 5, 962 (1976).Google Scholar
  6. 6.
    G. I. Shul'gina, Bioelectric Cerebral Activity and the Conditioned Reflex [in Russian], Nauka, Moscow.Google Scholar
  7. 7.
    G. I. Shul'gina and A. V. Korinevskii, “The reinforcing stimulus and its mechanism of action,” Zh. Vyssh. Nerv. Deyat.,25, No. 5, 1011 (1975).Google Scholar
  8. 8.
    G. I. Shul'gina and I. V. Pavlova, “The role of cholinergic inhibition and disinhibiting influences in the mechanism of reinforcement and internal inhibition,” Zh. Vyssh. Nerv. Deyat.,32, No. 4, 616 (1982).Google Scholar
  9. 9.
    S. P. Duckies and S. H. Buck, “Substance P in the cerebral vasculature: depletion by capsaican suggests a sensory role,” Brain Res.,245, No. 1, 171 (1982).Google Scholar
  10. 10.
    U. S. Euler and J. H. Gaddum, “An unidentified depressor substance in certain tissue extracts,” J. Physiol.,72, No. 1, 74 (1931).Google Scholar
  11. 11.
    R. C. A. Frederickson and P. D. Gesellchen, “Analgesic and other activities of substance P and fragments,” in: Neuropeptides and Neural Transmission, Proceedings of UNESCO-IBRO Symposium, Jablonna, June 2–4, 1979, New York (1980), p. 111.Google Scholar
  12. 12.
    V. Fujita and T. Sato, “Intracellular records from hippocampal pyramidal cells in the rabbit during theta rhythm activity,” J. Neurophysiol.,27, No. 6, 1011 (1964).Google Scholar
  13. 13.
    K. Hecht, P. Dehme, I. Ljowschina, M. Poppei, E. Wachtel, and M. Airapetjanz, “Peptide als lern- und gedächtnisaktive Substanzen,” Wissenschaftliche Zeitschr. der Humboldt, Univ. Berlin, Math., Nat. R.,29, 655 (1980).Google Scholar
  14. 14.
    J. D. Naranjo and J. Del Rip, “Differential effects of D-Ala2-analogues of enkephalins on substance P-induced analgesia in rodents,” Eur. J. Pharmacol.,82, No. 3–4, 213 (1982).Google Scholar
  15. 15.
    P., Oehme, M. Bienert, K. Hecht, and J. Bergmann, “Substanz P Ausgewählte Probleme der Chemie, Biochemie, Pharmakologie, Physiologie und Pathophysiologie.” Heft 12, Beitrage zur Wirkstofforsch., DDR, Berlin (1981), pp. 128, 142, 155.Google Scholar
  16. 16.
    M. Randic, E. Carstens, M. Zimmermann, and D. Klumpp, “Dual effects of substance P on the excitability of single cutaneousprimari afferent C and A fibers in the cat spinal cord,” Brain Res.,233, No. 2, 389 (1982).Google Scholar
  17. 17.
    P. Skrabanek and D. Powell, “Substance P,” in: Annual Research Reviews, Vol. 2, Eden Press Inc. (1980).Google Scholar
  18. 18.
    Z. Screniawski, A. Czionkowski, P. Janicki, J. Libich, and S. W. Gumilka, “Pain transmission and analgesia,” in: Neuropeptides and Neural Transmission, Proceedings of UNESCO-IBRO Symposium, Jablonna, June 2–4, 1979, New York (1980), p. 121.Google Scholar
  19. 19.
    G. W. Tregear, H. D. Niall, J. T. Potts, Jr., S. E. Leeman, and M. M. Chang, “Synthesis of substance P,” Nature New Biol. (London),232, 87 (1971).Google Scholar
  20. 20.
    S. Watanabe, M. Konishi, and O. Creutzfeldt, “Postsynaptic potentials in the cat's visual cortex following electrical stimulation of afferent pathways,” Exptl. Brain Res.,1, No. 3, 272 (1966).Google Scholar
  21. 21.
    A. M. Wein, K. Radaschak, R. Biniauraschwwili, P. Oehme, and K. Hecht, “Substanz P-Blutspiegel in der Vorschlafperiode von schlafgestörten Neurotikern und Patienten mit Smerzsyndrom (vorläufige Mitteilung),” in: Experimentelle Neurose, Issue No. 3, Humboldt, Univ. Berlin (1980), p. 757.Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • G. I. Shul'gina
    • 1
    • 2
  • I. P. Levshina
    • 1
    • 2
  • A. M. Melekhova
    • 1
    • 2
  • K. Hecht
    • 1
    • 2
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyAcademy of Sciences of the USSRMoscow
  2. 2.Humboldt UniversityBerlin

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