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Neuroscience and Behavioral Physiology

, Volume 21, Issue 2, pp 149–153 | Cite as

Parasympathetic control of the spontaneous defibrillation of the heart ventricles in animals of various ages

  • V. I. Kobrin
Article

Abstract

The role of the parasympathetic division of the nervous system in the process of the spontaneous defibrillation of the heart ventricles in guinea pigs of various ages has been investigated. It was shown that the intensification of parasympathetic control in newborn and sexually mature animals by means of the stimulation of the vagus nerves through the administration of acetylcholine leads to an increase in the duration of ventricular fibrillation, while in old animals this leads to the possibility of its prevention. The important role of the maintenance of sympathetic control in the mechanisms of the recovery of normal cardiac rhythm has been demonstrated.

Keywords

Nervous System Acetylcholine Ventricular Fibrillation Vagus Nerve Cardiac Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

  1. 1.
    O. M. Avakyan,The Sympathoadrenal System. Methods of the Investigation of the Secretion, Reception, and Uptake of the Catecholamines [in Russian], Nauka, Leningrad (1977).Google Scholar
  2. 2.
    W. K. De Mello,Intercellular Intercommunication [in Russian], Meditsina, Moscow (1980).Google Scholar
  3. 3.
    V. I. Kobrin, G. I. Kositskii, and N. B. Khaspekova, “A microelectrode investigation of the defibrillation of the ventricles of the heart,”Kardiologiya,20, No. 8, 48–54 (1980).Google Scholar
  4. 4.
    G. I. Kositskii, N. B. Khaspekova, and V. I. Kobrin, “The possibility of a change in the function of the intercalated disks of the myocardium during the action of neurotropic substances,”Fiziol. Zh. AN SSSR,71, No. 9, 1078–1080 (1985).Google Scholar
  5. 5.
    G. I. Kositskii, V. I. Kobrin, N. B. Khaspekova, et al., “The influence of the nervous system on the processes of intercellular interactions in the myocardium,” in:Abstracts of Reports of the 13th All-Union Congress of Physiologists, Vol. 1 [in Russian], Alma-Ata (1979).Google Scholar
  6. 6.
    B. Lown and R. L. Verier, “The influence of the parasympathetic nervous system on the stability of the electrical activity of the ventricles of the heart,”Sudden Death. Materials of the Second Soviet-American Symposium [in Russian], Meditsina, Leningrad (1982).Google Scholar
  7. 7.
    B. M. Fedorov,Mechanisms of the Disturbance and Restoration of Cardiac Activity [in Russian], Meditsina, Moscow (1968).Google Scholar
  8. 8.
    E. I. Chazov and V. M. Bogolyubov,Disturbance of Cardiac Rhythm [in Russian], Meditsina, Moscow (1972).Google Scholar
  9. 9.
    J. H. Burn and M. J. Rand, “Acetylcholine in adrenergic transmission,”Ann. Rev. Pharmacol., 5, 163–192 (1965).Google Scholar
  10. 10.
    K. M. Kent, S. E. Epstein, T. Cooper, et al., “Cholinergic innervation of the canine and human ventricular conducting system: anatomic and electrophysiologic correlation,”Circulation, 50, No. 5, 948–955 (1974).Google Scholar
  11. 11.
    L. Szekeres, “Role of the autonomic nervous system in the mechanism of cardiac rhythm disturbances,”Adv. Physiol. Sci., No. 9, 57–65 (1981).Google Scholar
  12. 12.
    M. S. Yoon, J. Han, W. W. Tae, et al., “Effects of vagal stimulation, atropine and propranolol on fibrillation threshold of normal and ischemic ventricles,”Amer. Heart J., 93, No. 1, 60–65 (1977).Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • V. I. Kobrin
    • 1
  1. 1.Department of Normal PhysiologyN. I. Pirogov Second State Medical InstituteMoscow

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