The anesthetics studied exist primarily in the cationic form at pH 3.5, 5.0, 6.0, 7.0, and 7.35.
The concentration of the ionized form of an anesthetic in the nerve at various external pH values is more constant in comparison with the concentration of the nonionized base.
The nonionized base is important for the penetration of the anesthetic to the reaction site; the cationic form is responsible for the interaction of the anesthetic with the receptor.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 1, pp. 35–39, January, 1970.
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Pryanishnikova, N.T. Degree of ionization and active form of anesthetics. Pharm Chem J 4, 33–37 (1970). https://doi.org/10.1007/BF01159410
- Organic Chemistry
- Active Form
- Reaction Site
- Cationic Form
- Nonionized Base