Neuroscience and Behavioral Physiology

, Volume 16, Issue 4, pp 285–289 | Cite as

Nuclease sensitivity and methylation of liver chromatin DNA in rats in initial period of effect of glucocorticoids

  • G. A. Romanov
  • E. N. Zhavoronkova
  • S. V. Savel'ev
  • B. F. Vanyushin


  1. 1.

    Sensitivity of chromatin DNA of rat liver to DNase I and the level of its methylation do not change noticeably 3.5 h after administration of an inducing dose of hydrocortisone to animals.

  2. 2.

    Loci activated by glucocorticoids must initially possess potentially active conformation sensitive to DNase I.



Hydrocortisone Glucocorticoid Initial Period Active Conformation Liver Chromatin 
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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • G. A. Romanov
    • 1
  • E. N. Zhavoronkova
    • 1
  • S. V. Savel'ev
    • 1
  • B. F. Vanyushin
    • 1
  1. 1.A. N. Belozerskii Interdepartmental Laboratory of Molecular Biology and Bioorganic ChemistryMoscow State UniversityMoscow

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