Catalytic conversion of furan amines into pyridine and pyrazine derivatives
Organic Chemistry
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Conclusions
- 1.
The hydrogenation of furan amines containing an amino group in the side chain adjacent to the furan ring in the presence of a Pt catalyst under continuous-flow conditions at 220–250°C proceeds via two parallel routes, viz., elimination of the amino group in the form of ammonia to form furan homologs, and primary hydrogenolysis of the furan ring without elimination of the amino group to form pyridine and pyrazine homologs.
- 2.
Hydrogenation of furan amines under continuous-flow conditions in the presence of a Raney Cu-Al catalyst under a pressure of hydrogen results in the formation of piperazine and piperidine homologs.
Keywords
Hydrogenation Ammonia Pyridine Furan Piperidine
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Publishing Corporation 1977