Neurosurgical Review

, Volume 20, Issue 2, pp 117–123

Multiple meningiomas of the central nervous system without the stigmata of neurofibromatosis. Clinical and therapeutic study

  • Mehmet Turgut
  • Selçuk Palaoğlu
  • Osman Ekin Özcan
  • Özdemir Gürçay
  • Muzaffer Eryilmaz
Article

Abstract

Multiple meningiomas are relatively rare tumors without known neurofibromatosis. In this paper, such eight cases of multiple meningiomas as described byCushing andEisenhardt are presented. Certain aspects of diagnosis and surgical management of this rare condition are discussed with particular emphasis on the importance of the distinction among multiple meningioma, meningiomatosis, or recurrences of these tumors. Fortunately, many of these patients tolerate multiple surgical interventions well, although the removal of these tumors in critical areas is a difficult problem. Thus, we think that it is important to examine and supervise all patients who have had a meningioma for a possible occurence of a second meningioma.

Keywords

Brain tumor meningioma meningiomatosis multiple meningiomas neurofibromatosis 

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References

  1. [1]
    Bonnal J, JD Born, M Tremoult: Meningiomas multiples intracraniens. Neurochirurgie 25 (1979) 78–83PubMedGoogle Scholar
  2. [2]
    Butti G, R Assieltti, R Casolone, P Paoletti: Multiple meningiomas: A clinial, surgical, and cytogenetic analysis. Surg Neurol 31 (1989) 255–260PubMedGoogle Scholar
  3. [3]
    Çetinalp E, S Haciyakupoğlu, Y Tanyas, H Bağ-datoğlu, M Taşkin, C Yücesoy: Multipl menenjiomlar. Çkurova Üniv Tip Fak Dergisi 8 (1983) 250–255Google Scholar
  4. [4]
    Crouse SK, BO Berg: Intracranial meningiomas in childhood and adolescence. Neurology 22 (1972) 135–141PubMedGoogle Scholar
  5. [5]
    Cushing H, L Eisenhardt Meningiomas: Their classification, regional behaviour, life history, and surgical end results. Charles C Thomas, Springfield Ill 1938Google Scholar
  6. [6]
    Deda H, E Arasil, C Dinçer, E Çakiroğlu: Multiple spinal cord meningiomas. Turkish Neurosurgery 2 (1991) 36–38Google Scholar
  7. [7]
    Distelmaier P, E Lins, T Kolberg: Multiple meningiomas. Neurochirurgia 19 (1976) 114–117PubMedGoogle Scholar
  8. [8]
    Domenicucci M, A Santoro, DH D'Osvaldo, R Delfini, GP Cantore, B Guidetti: Multiple intracranial meningiomas. J Neurosurg 70 (1989) 41–44PubMedGoogle Scholar
  9. [9]
    Eljamel MSM, PM Foy: Multiple meningiomas and their relation to neurofibromatosis. Surg Neurol 32 (1989) 131–136PubMedGoogle Scholar
  10. [10]
    Frazier CH, BJ Alpers: Meningeal fibroblastomas of cerebrum: A clinicopathologic analysis of seventy-five cases. Arch Neurol Psychiatry 29 (1933) 935–989Google Scholar
  11. [11]
    Friedmann T: Progress toward human gene therapy. Science 244 (1989) 1275–1281PubMedGoogle Scholar
  12. [12]
    Gokalp HZ, E Arasil, A Erdoğan, N Egemen, S Naderi: Multiple intracranial meningiomas. Neurochirurgia 35 (1992) 95–96PubMedGoogle Scholar
  13. [13]
    Inagawa S, H Yamakawa, M Nishikawa: Triple primary brain tumors of different histological types: Case report. Surg Neurol 41 (1994) 52–55PubMedGoogle Scholar
  14. [14]
    Kars Z, F Ergüngör, O Gürçay, B Onol: Multiple meningiomas involving the orbit and the cranial cavity. J Clin Neuro-ophthalmol 3 (1983) 119–122Google Scholar
  15. [15]
    Lekanne Deprez RH, NA Groen, D Louz, A Hagemeijer, E van Drunen, JW Koper, CJ Avezaat, D Bootsma, TH van der Kwast, EC Zwarthoff: Con stitutional DNA-level aberrations in chromosome 22 in a patient with multiple meningiomas [review]. Genes, Chromosomes & Cancer 9 (1994) 124–128Google Scholar
  16. [16]
    Levin P, SW Gross, LI Malis, AH Kirshenbaum, SA Hollin: Multiple intracranial meningiomas. Surg Gynecol Obstet 119 (1964) 1085–1090PubMedGoogle Scholar
  17. [17]
    Lusins JO, H Nakagawa: Multiple meningiomas evaluated by computed tomography. Neurosurgery 9 (1981) 137–141PubMedGoogle Scholar
  18. [18]
    Luyendijik W: Meningiomes multiples et meningiomatoses. Acta Neurochir 3 (1954) 263–274Google Scholar
  19. [19]
    Mufson JA, LM Davidoff: Multiple meningiomas. Report of two cases. J Neurosurg 1 (1944) 45–57Google Scholar
  20. [20]
    Nahser HC, W Grote, E Löhr, L Gerhard: Multiple meningiomas: Clinical and computer tomographic observations. Neuroradiology 21 (1981) 259–263PubMedGoogle Scholar
  21. [21]
    Nakasu S, A Hirano, T Shimura, JF Liena: Incidental meningiomas in autopsy study. Surg Neurol 27 (1987) 319–322PubMedGoogle Scholar
  22. [22]
    Namer IJ, MN Pamir, K Benli, S Saglam, A Erbengi: Spinal meningiomas. Neurochirurgia 30 (1987) 11–15PubMedGoogle Scholar
  23. [23]
    Neurofibromatosis Conference Statement. National Institutes of Health Consensus Development Conference. Arch Neurol 45 (1988) 575–578Google Scholar
  24. [24]
    Pagni CA, S Canavero, A Cento: Multiple spinal meningiomas: Case report and review of the literature. Zentrbl Neurochir 51 (1990) 225–228Google Scholar
  25. [25]
    Palaoğlu S, F Gezen, Ş Ünlü, T Bilge, A Bedük, ON Akin: Multiple meningioma olgusu. GATA Bülteni 27 (1985) 783–787Google Scholar
  26. [26]
    Payne CS, AD Roses: The molecular genetic revolution: Its impact on clinical neurology. Arch Neurol 45 (1988) 1366–1376PubMedGoogle Scholar
  27. [27]
    Petrella R, S Levine, PL Wilmot, KD Ashar, AC Casamassima, LR Shapiro: Multiple meningiomas in a patient with constitutional ring chromosome 22. Am J Med Genet 47 (1993) 184–186PubMedGoogle Scholar
  28. [28]
    Pulst SM, GA Rouleau, C Marineau, P Fain, JP Sieb: Familial meningioma is not allelic to neurofibromatosis 2. Neurology 43 (1993) 2096–2098PubMedGoogle Scholar
  29. [29]
    Seizinger BR, S de la Monte, L Atkins, JF Gusella, RL Martuza: Molecular genetic approach to human meningioma: Loss of genes on chromosome 22. Proc Natl Acad Sci USA 84 (1987) 5419–5423PubMedGoogle Scholar
  30. [30]
    Sheehy JP, HA Crockard: Multiple meningiomas: a long-term review. J Neurosurg 59 (1983) 1–5PubMedGoogle Scholar
  31. [31]
    Taren JA: Meningiomas. In:Kahn EA, EC Crosby, RC Schneider (eds): Correlative Neurosurgery Charles C Thomas, Springfield Ill 1969Google Scholar
  32. [32]
    Tönnis D: Die Meningiome. Acta Neurochir 13 (1965) 308–310Google Scholar
  33. [33]
    Turgut M, OE Özcan, S Sağlam: Central neurofibromatosis. Eur Neurol 31 (1991) 188–192PubMedGoogle Scholar
  34. [34]
    Vestergaard E: Multiple intracranial meningiomas. Acta Psychiat Neurol (Kbh.) 19 (1944) 389–411Google Scholar
  35. [35]
    Waga S, M Matsuda, H Handa, M Matsushima, K Ando: Multiple meningiomas. Report of four cases. J Neurosurg 37 (1972) 348–351PubMedGoogle Scholar
  36. [36]
    Wood NW, RW White, JW Kernohan: One hundred intracranial meningiomas found incidentally at necropsy. J Neuropathol Exp Neurol 16 (1957) 337–340PubMedGoogle Scholar
  37. [37]
    Zervas N, A Shintani, B Kallar, R Berry: Multiple meningiomas occupying separate neuraxial compartments. Case report. J Neurosurg 33 (1970) 216–220PubMedGoogle Scholar

Copyright information

© Walter de Gruyter & Co 1997

Authors and Affiliations

  • Mehmet Turgut
    • 1
    • 4
  • Selçuk Palaoğlu
    • 2
  • Osman Ekin Özcan
    • 2
  • Özdemir Gürçay
    • 2
  • Muzaffer Eryilmaz
    • 3
  1. 1.Department of NeurosurgeryAdrian Menderes University Medical FacultyAydin
  2. 2.Department of NeurosurgeryHacettepe University Medical FacultyAnkaraTurkey
  3. 3.Department of RadiologyHacettepe University Medical FacultyAnkaraTurkey
  4. 4.Meşrutiyet Mahallesi Gençlik CaddesiAydinTurkey

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