Differences in the luteal phases after failed or successful in vitro fertilization and embryo replacement
Luteal phases after in vitro fertilization (IVF) and embryo replacement have been studied in 241 cycles. A positive correlation was observed between the follicular estradiol (E2) peak and the progesterone (P) level on day 3 of the luteal phase, but not correlation was found between the E2-peak value and the luteal-phase duration or midluteal P concentration. When the trials were classified in relation to their outcome (i.e., clinical pregnancies, chemical pregnancies, or failures), the mean P level on day 3 of the luteal phase was significantly higher in clinical pregnancies than in chemical pregnancies and in failures. Mean E2 levels on day 3 were not significantly different among the three groups. Values of the E2/P ratio were significantly higher in chemical pregnancies than in the other groups. No significant differences were observed among the three groups on day 8. When comparing trials ending in failure to those leading to clinical pregnancy for the same patients, pregnancies were obtained in cycles in which early luteal P was higher and the early luteal E2/P ratio was lower than in failures cycles. These data suggest that high P levels and a low E2/P ratio in the early luteal phase might have a favorable influence on the implantation process in human IVF.
Key Wordsin vitro fertilization luteal phase implantation
Unable to display preview. Download preview PDF.
- 2.Camus M, Puissant F, Deweze-Van Hoeck J, Leoroy F: Development and quality of IVF trials. Abstracts Handbook-IVth World Conference onin Vitro Fertilization. Melbourne, Australia, Nov. 18–22, 1985Google Scholar
- 16.Lenton EA, Adams M, Cooke ID: Plasma steroid and profiles in ovulatory but infertile women. Clin Endocrinol (oxford) 1978;8:241–255Google Scholar
- 17.Seppälä M, Lehtovirta P, Rutawen EM: Detection of chorionic gonatropin activity in infertile cycles with a short luteal phase. Acta Endocrinol (Kbh( 1978;88:164–168Google Scholar
- 18.Lenton EA, Sulaiman R, Sobowale O, Cooke ID: The human menstrual cycle: plasma concentrations of prolactin, LH, FSH, oestradiol and progesterone in conceiving and non-conceiving women. J Reprod Fert 1982;65:131–139Google Scholar
- 20.Lejeune B, Dehou MF, Leory F: Tentative extrapolation of animal data to human implantation. NY Acad Sci (in press) 1986Google Scholar
- 22.Jones HW, Acosta A, Andrews MC, Garcia JE, Jones GS, Mahntzavinos T, McDowell J, Sandow B, Veeck L, Whibley T, Wilkes C, Wright G: The importance of the follicular phase to success and failure inin vitro fertilization. Fertil Steril 1973;40:317–321Google Scholar
- 23.Edwards RG:In The Current Clinical and Ethical Situation of Human Reproduction and Their Eugenic, Ethical Implications, CO Carter (ed). London, Academic Press, 1983Google Scholar
- 26.Lehman F, Just-Nastansky I, Behrendt B, Crygau PJ, Bettendorf B: Effect of postovulatory administered oestrogens on corpus luteum function. Acta Endocrinol (Kbh) 1975;79:329–336.Google Scholar