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Combined clomiphene citrate (CC) and human menopausal gonadotropins (hMG) in a fixed schedule for follicular recruitment during in vitro fertilization: Effects on premature luteinizing hormone (LH) surges

  • Josef Blankstein
  • Robert L. Collins
  • Kirk A. Easley
  • Manjula K. Gupta
  • Martin M. Quigley
Short Communications

Summary

Recognizing the association between plasma progesterone (P) and an imminent LH surge, we investigated the frequency of P elevation in our stimulation protocol (clomiphene citrate-human menopausal gonadotropins). P was measured retrospectively on the day before, the day of, and the day after human chorionic gonadotropin hCG administration. The means ±2 standard deviations for P were as follows: day before hCG, 0.58±0.86; day of hCG, 0.64 ± 0.56; and day after hCG, 1.47 ± 1.22. Seven patients (8%) had P levels greater than 2 SD above the mean.

Significant P elevations prior to hCG are infrequent with this protocol, and in the few patients with raised P a trend toward lowered fertilization was noted. The low incidence of P elevation may be secondary to the administration of hCG in a timely manner on the sixth day of estradiol (E2) rise.

Keywords

Standard Deviation Citrate Progesterone Estradiol Developmental Biology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Josef Blankstein
    • 1
    • 2
    • 3
  • Robert L. Collins
    • 1
    • 2
    • 3
  • Kirk A. Easley
    • 1
    • 2
    • 3
  • Manjula K. Gupta
    • 1
    • 2
    • 3
  • Martin M. Quigley
    • 1
    • 2
    • 3
  1. 1.Department of GynecologyCleveland Clinic FoundationCleveland
  2. 2.Department of ImmunopathologyCleveland Clinic FoundationCleveland
  3. 3.Department of BiostaticsCleveland Clinic FoundationCleveland

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