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EEG reactivity in high and low symptomatic schizophrenics, using source modelling in the frequency domain

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Summary

A dipole localization method in the frequency domain was used (FFT Dipole Approximation) to assess spatial differences in the spectral EEG reactivity (orienting response) between high and low symptomatic schizophrenics. Frequency bands of interest were determined empirically by comparing the two dichotomized patient groups with two matched control groups. Evidence for a correlation between EEG reactivity and severity of schizophrenic symptomatology was found, especially in the higher beta frequency range (16 – 25.5 Hz). Opposite effects were found in the two beta ranges of 20.5–22.5 Hz and 23.0–25.5 Hz, supporting the hypothesis that different EEG frequency bands have specific functional significances and that these bands are not necessarily those that are conventionally selected.

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References

  1. "AMDP" Arbeitsgemeinschaft für Methodik und Dokumentation in der Psychiatrie (Ed.), Das AMDP-System. Manual zur Dokumentation psychiatrischer Befunde. Berlin: Springer, 1979.

  2. Costello, C.G. Classification and Psychopathology. In C.G. Costello (Ed.), Symptoms of Psychopathology, New York: John Wiley and Sons, 1970: 1–26.

  3. Costello, C.G. Research on symptoms versus research on syndromes. Arguments in favour of allocating more research time to the study of symptoms. Brit. J. Psychiat. 1992, 160: 304–308.

  4. Dierks, T. Equivalent EEG sources determined by FFT Approximation in healthy subjects, schizophrenic and depressive patients. Brain Topography, 1992, 4: 207–213.

  5. Galderisi, S., Mucci, A., Mignone, M.L., Maj, M. and Kemali, D. QEEG mapping in drug-free schizophrenics: differences from healthy subjects and changes induced by haloperidol treatment. Schizophr. Res., 1992, 6: 15–24.

  6. Grass, P., Lehmann, D., Meier B., Meier, C.A. and Pal, I. Sleep onset: factorization and correlations of spectral EEG parameters and mentation rating parameters. Sleep Res., 1987, 16: 231.

  7. Herrmann, W.M. Development and critical evaluation of an objective procedure for the electroencephalographic classification of psychotropic drugs. In W.M. Herrmann (Ed.), Electroencephalography in Drug Research. Stuttgart: Fischer, 1982: 249–351.

  8. Itil, T.M., Saletu, B. and Davis, S. EEG findings in chronic schizophrenics based on digital computer period analysis and analog power spectra. Biol. Psychiat., 1972, 5: 1–13.

  9. John, E.R., Prichep, L.S., Fridman, J. and Easton, P. Neurometrics: Computer-assisted differential diagnosis of brain dysfunctions. Science, 1988, 239: 162–169.

  10. Koukkou, M. EEG reactivity in acute schizophrenics reflects deviant (ectropic) state changes during information processing. In: M. Koukkou, D. Lehmann and J. Angst (Eds.), Functional States of the Brain: their Determinants. Amsterdam: Elsevier, 1980: 265–290.

  11. Koukkou, M. EEG states of the brain, information processing and schizophrenic primary symptoms. Psychiat. Res., 1982, 6: 235–244.

  12. Koukkou, M. and Lehmann, D. An information processing perspective of psychophysiological measurements. J. Psychophysiol. 1987, 1: 109–112.

  13. Koukkou, M. and Manske, W. Functional states of the brain and schizophrenic states of behavior. In: C. Shagass, R.C. Josiassen and R.A. Roemer (Eds.), Brain Electrical Potentials and Psychopathology. New York: Elsevier, 1986: 91–114.

  14. Koukkou, M., Bigler, M. and Lehmann, D. Central components of the orienting response (EEG reactivity) in acute and former schizophrenics, neurotics and normals. Adv. Biol. Psychiat., 1982, 9: 20–27.

  15. Koukkou, M., Tremel, E. and Manske, W. A psychobiological model of the pathogenesis of schizophrenic symptoms. Int. J. Psychophysiol., 1991, 10: 203–212.

  16. Lehmann, D. and Michel, C.M. Intracerebral dipole sources of EEG FFT power maps. Brain Topography, 1989, 2: 155–164. (Erratum: 1990, 2: 311.)

  17. Lehmann, D. and Michel, C.M. Intracerebral source localization for FFT power maps. Electroenceph. Clin. Neurophysiol., 1990, 76: 271–276.

  18. Lehmann, D., Michel, C.M., Henggeler, B. and Brandeis, D. Source localization of spontaneous EEG using FFT Approximation: Different frequency bands, and differences with classes of thought. In: I. Dvorak (Ed.), Mathematical Approaches to Brain Functional Diagnosis. Manchester: University Press, 1991: 159–169.

  19. Michel, C.M., Lehmann, D., Henggeler, B. and Brandeis, D. Localization of the sources of the EEG Delta, Theta, Alpha, and Beta bands using the FFT Dipole Approximation. Electroenceph. Clin. Neurophysiol., 1992, 82: 38–44.

  20. Strauss, J.S. Hallucinations and delusions as points on continua function: rating scale evidence. Arch. Gen. Psychiat., 1969, 21: 581–586.

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Author information

Correspondence to Christoph M. Michel.

Additional information

We thank W. Manske and E. Tremel for their collaboration in conducting the recordings and initial steps of data treatment, and Dr. R. D. Pascual-Marqui for his contribution to the statistical analysis of the data.

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Michel, C.M., Koukkou, M. & Lehmann, D. EEG reactivity in high and low symptomatic schizophrenics, using source modelling in the frequency domain. Brain Topogr 5, 389–394 (1993). https://doi.org/10.1007/BF01128696

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Keywords

  • EEG reactivity
  • Orienting response
  • Acute schizophrenia
  • FFT Dipole Approximation
  • Frequency domain
  • Model dipole sources