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Functional changes in degenerating central synaptic endings


Intracellular recording of the EPSP's of spinal motoneurons activated monosynaptically by impulses from normal and previously divided (24–36 hr beforehand) afferent fibers demonstrated essential differences in the trans-synaptic action of their endings. These differences may be regarded as the consequence of rapid exhaustion during repetitive excitation of stores of transmitter immediately available for release from the endings of the degenerating nerve fibers.

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Kostyuk, P.G., Savos'kina, L.A. Functional changes in degenerating central synaptic endings. Neurosci Behav Physiol 1, 73–80 (1967).

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  • Nerve Fiber
  • Functional Change
  • Afferent Fiber
  • Essential Difference
  • Intracellular Recording