Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations

  • Kiyoshi Yamaoka
  • Terumichi Nakagawa
  • Toyozo Uno
Article

Abstract

According to linear pharmacokinetics, the time course of plasma concentration of a drug, Cp,is expressed by a sum of exponential functions, Cpi=1nai\(C_p = \sum\nolimits_{i = 1}^n {a_i e^{ - b_i t} } \).This article describes a statistical technique to estimate the number of exponential terms, n,for the time course of drug by the application of Akaike's information criterion (AIC). Plasma concentrations of ethoxybenzamide, sulfisoxazole, bishydroxycoumarin, and diazepam measured following bolus intravenous injection were used as clinical examples for this method. Selection of models is compared between the AIC method and an Ftest method at significance levels of 5% and 1%.

Key words

linear pharmacokinetic equations number of exponential terms amount of information in the time course Akaike's information criterion (AIC) F test ethoxybenzamide sulfisoxazole bishydroxycoumarin diazepam 

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Kiyoshi Yamaoka
    • 1
  • Terumichi Nakagawa
    • 1
  • Toyozo Uno
    • 1
  1. 1.Faculty of Pharmaceutical SciencesKyoto UniversityKyotoJapan

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