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Die Wegenersche Granulomatose

Wegener's Granulomatosis. Diagnosis and therapy. A report on 16 cases


The Wegener Granulomatosis (W. G.) is a rare disease of uncertain origin and with primary manifestation in the oto-rhinologic field becoming more and more of interest. With 10 of 16 cases first subjective symptoms were in the upper respiratory tract. With further development of the disease, there was involvement of the trachea, lungs and kidney. The diagnosis could be ensured or at least be presumed histologically by biopsies in the oto-rhino-laryngologic field. Multiple endoscopic biopsies from the larynx, trachea and paranasal sinuses as well as radiologic examination are of decising importance for diagnosis. If a W. G. is only suspected, an additional internal examination is necessary, because often only clinical, radiological and histological findings in combination with the development can ascertain diagnosis. For differential diagnosis neoplasms, specific and unspecific infection have to be hold in mind but especially the Granuloma gangraenescens because therapy is different. The treatment of choice in W. G. is cyclophosphamid that has improved considerably the prognosis of W. G.

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Beigel, A., Lehmann, H., Müller-Hermelink, K.H. et al. Die Wegenersche Granulomatose. Arch Otorhinolaryngol 223, 216 (1979).

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